CRFR (Corticotropin-releasing Factor Receptor), also known as corticotropin-releasing hormone receptor (CRHR), belongs to the G protein-coupled receptor family. There are 3 types of this recetpor, CRF1, CRF2 and CRF3 receptor. CRF1 receptor (CRF1 or CRF1α) is functionally coupled to adenylate cyclase and it belongs to the secretin-like, family B of GPCRs. CRF1 receptor has several splice variants (CRF1c-CRF1m) including CRF1β. CRF2 receptor is a 411-amino acid protein with approximately 70% identity to the known CRF1 and it is functionally coupled to adenylate cyclase. The CRF2 receptor has been shown to be expressed as three functional splice variants, the CRF2α (411-413 amino acids), the CRF2β (431-438 amino acids) and the CRF2γ (397 amino acids). CRF3 receptor is a 428-amino acid protein, which binds CRF with a 5-fold higher affinity than URO and SVG and is expressed in the pituitary gland, urophysis, and brain.

CRFR subserves central functions related to stress physiology, and also exerts peripheral actions relevant to cardiovascular, muscular, gastrointestinal, pancreatic, inflammatory, and neoplastic diseases.


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α-Helical CRF (12-41) trifluoroacetate salt

a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect[1][2].

  • CAS Number: 158535-55-8
  • MF: C152H251N43O47S2
  • MW: 3497.009
  • Catalog: CRFR
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Urocortin III (mouse) trifluoroacetate salt

Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2[1].

  • CAS Number: 357952-10-4
  • MF: C186H312N52O52S2
  • MW: 4172.97
  • Catalog: CRFR
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 536.7±23.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 292.4±19.1 °C

α-Helical CRF (9-41) trifluoroacetate salt

α-Helical Corticotropin Releasing Factor (9-41) is a corticotropin releasing factor (CRF) antagonist. α-Helical Corticotropin Releasing Factor (9-41) decreases plasma growth hormone (GH) values in vivo[1][2].

  • CAS Number: 99658-03-4
  • MF: C166H274N46O53S2
  • MW: 3826.36
  • Catalog: CRFR
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 717.1±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 387.5±32.9 °C

(Tyr0)-Urocortin (rat)

(Tyr0)-Urocortin, rat is a high-affinity agonist of corticotropin-releasing factor receptor type 1 (CRF-R1) and type 2 (CRF-R2). (Tyr0)-Urocortin, rat shows inhibitory binding constants (Ki) of 1-2 nM[1].

  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

CRF (bovine) trifluoroacetate salt

CRF,bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.

  • CAS Number: 92307-52-3
  • MF: C206H340N60O63S
  • MW: 4697.34
  • Catalog: Peptides
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

(D-Phe11,His12)-Sauvagine (11-40)

Antisauvagine-30 (aSvg-30) is a potent, competitive and selective CRF2 receptor antagonist with Kd values of 1.4 nM and 153.6 nM for mouse CRF2β and rat CRF1 receptors, respectively[1].

  • CAS Number: 220673-95-0
  • MF: C161H274N48O46S
  • MW: 3651.24000
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Urocortin human

Urocortin, human, a 40-aa neuropeptide, acts as a selective agonist of endogenous CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for hCRF1, rCRF2α and mCRF2β, respectively.

  • CAS Number: 176591-49-4
  • MF: C204H337N63O64
  • MW: 4696.24
  • Catalog: Peptides
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Urocortin rat

Urocortin, rat is a selective agonist of CRF receptor, with Kis of 0.32, 2.2, and 0.62 nM for hCRF1, rCRF2α and mCRF2β, respectively.

  • CAS Number: 171543-83-2
  • MF: C206H338N62O64
  • MW: 4707.26
  • Catalog: Peptides
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

JTC-017

JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats[1].

  • CAS Number: 357330-77-9
  • MF: C20H25Cl2N3O5S
  • MW: 490.40100
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Pexacerfont

Pexacerfont is a selective corticotropin-releasing factor (CRF1) receptor antagonist with IC50 of 6.1±0.6 nM for human CRF1 receptor.

  • CAS Number: 459856-18-9
  • MF: C18H24N6O
  • MW: 340.42300
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

[DPro5] Corticotropin Releasing Factor, human, rat

[DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat[1].

  • CAS Number: 195628-97-8
  • MF: C208H344N60O63S2
  • MW: 4757.45
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Urotensin I

Urotensin I is, 41-aa neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively.

  • CAS Number: 83930-33-0
  • MF: C210H340N62O67S2
  • MW: 4869.46
  • Catalog: Peptides
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 1402.8±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 802.2±34.3 °C

Emicerfont

Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM.

  • CAS Number: 786701-13-1
  • MF: C22H24N6O2
  • MW: 404.46500
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Urocortin II (mouse) trifluoroacetate salt

Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with Ki values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca2+/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow[1][2][3].

  • CAS Number: 330648-32-3
  • MF: C187H320N56O50
  • MW:
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

NVS-CRF38

NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility.IC50 value: Target: CRF1 antagonist

  • CAS Number: 1207258-55-6
  • MF: C19H21N5O2
  • MW: 351.40200
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Urocortin III (human) trifluoroacetate salt

Urocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) selectively binds to type 2 CRF receptors with Ki values of 13.5, 21.7, and >100 nM for mCRF2β, rCRF2α, and hCRF1, respectively. Urocortin III (human) mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion[1][2].

  • CAS Number: 357952-09-1
  • MF: C185H307N53O50S2
  • MW:
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

α-Helical CRF(9-41)

α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM[1][2].

  • CAS Number: 90880-23-2
  • MF: C166H274N46O53S2
  • MW: 3826.40
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

CP 316311

CP 316311 is a potent and selective CRF1 receptor antagonist with an IC50 value of 6.8 nM.

  • CAS Number: 175139-41-0
  • MF: C21H29NO2
  • MW: 327.46
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

K41498

K41498 is a potent and highly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively hypotension. K41498 is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. K41498 can be used for hypotension study[1].

  • CAS Number: 434938-41-7
  • MF: C162H276N48O46
  • MW: 3632.22000
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

BMS-764459

BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical CYP1A1 inducer[1][2].

  • CAS Number: 1188407-45-5
  • MF: C19H21F2N5O3
  • MW: 405.39900
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

NBI 27914 hydrochloride

NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a Ki value of 1.7 nM[1][3][4].

  • CAS Number: 1215766-76-9
  • MF: C18H21Cl5N4
  • MW: 470.651
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Antalarmin

Antalarmin is a selective nonpeptide corticotropin-releasing factor receptor 1 (CRHR1) antagonist with a Ki of 2.7 nM. Antalarmin can pass through the blood–brain barrier[1][2][3].

  • CAS Number: 157284-96-3
  • MF: C24H34N4
  • MW: 378.55400
  • Catalog: CRFR
  • Density: 1.05g/cm3
  • Boiling Point: 437.2ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 218.2ºC

Sauvagine TFA

Sauvagine, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine is effective at releasing ACTH from rat pituitary cells. Sauvagine possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands[1][2][3].

  • CAS Number: 74434-59-6
  • MF: C202H346N56O63S
  • MW: 3334.68
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Tildacerfont

Tildacerfont is a novel corticotropin releasing factor (CRF) CRF1 receptor antagonist.

  • CAS Number: 1014983-00-6
  • MF: C20H26ClN5OS
  • MW: 419.971
  • Catalog: CRFR
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

BMS-665053

BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM)[1].

  • CAS Number: 1173435-64-7
  • MF: C16H14Cl3F2N3O2
  • MW: 424.65700
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Verucerfont

Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively.

  • CAS Number: 885220-61-1
  • MF: C22H26N6O2
  • MW: 406.48100
  • Catalog: CRFR
  • Density: 1.29
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

SN 003

SN003 is a reversible antagonist of corticotropin releasing factor receptor 1 (CRFR 1) (IC50 = 241 nM) that displays more than 1000-fold selectivity over CRFR 2. SN003 suppresses CRF-induced ACTH release in vitro. SN003 attenuates depressive-like behavior in rat[1][2][3].

  • CAS Number: 197801-88-0
  • MF: C19H25N5O2
  • MW: 355.43400
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

CP 376395 hydrochloride

CP 376395 hydrochloride is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist[1][2].

  • CAS Number: 1013933-37-3
  • MF: C21H31ClN2O
  • MW: 362.94
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

R-121919

R121919 is a potent small-molecule CRF1 receptor antagonist with a Ki of 2 to 5 nM for the CRF1 receptor and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types.

  • CAS Number: 195055-03-9
  • MF: C22H32N6
  • MW: 380.53000
  • Catalog: CRFR
  • Density: 1.114g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

CP 376395

CP 376395 is a potent and selective Corticotropin releasing factor 1 (CRF1) receptor antagonist.

  • CAS Number: 175140-00-8
  • MF: C21H30N2O
  • MW: 326.48
  • Catalog: CRFR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A