Dynamins are large superfamily GTPase proteins that are involved in various cellular processes including budding of transport vesicles, division of organelles, cytokinesis, and pathogen resistance. Dynamins are involved in scission (cleavage of the vesicle from the parent membrane) of nascent vesicles from parent membranes in eukaryotic cells. Dynamins interact directly with the lipid bilayer at the necks of clathrin-coated pits to sever and release coated vesicles. Dynamins contain five domains, including GTPase domain, middle domain, PH domain, GTPase effector domain (GED), and proline rich domain (PRD), while the dynamin-related proteins (DRPs) lack one or more of these domains or have additional domains. Dynamins and DRPs participate in a wide variety of cellular processes, including budding mitochondrial fission (mammalian Dlp1 and Saccharomyces cerevisiae Dnm1) and fusion (mammalian OPA1, S.cerevisiae Mgm1 and Schizosaccharomycespombe Msp1), vacuolar fission (S. cerevisiae Vps1), interferon-induced anti-viral protection (fish Mx proteins), plant cell cytokinesis and membrane fission (Arabidopsis thalianaDRP proteins), as well as pathogen resistance.


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Dynamin IN-1

Dynamin IN-1 is a potent dynamin inhibitor with an IC50 value of 1.0 µM[1].

  • CAS Number: 1345853-50-0
  • MF: C23H24N2O
  • MW: 344.45
  • Catalog: Dynamin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Dynole 34-2

Dynole 34-2 is a dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage[1]. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME)[2].

  • CAS Number: 1128165-88-7
  • MF: C25H36N4O
  • MW: 408.58000
  • Catalog: Dynamin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Clathrin-IN-2

Clathrin-IN-2 is potent inhibitor of clathrin mediated endocytosis (CME) with an IC50 value of 2.3 μM. Clathrin-IN-2 also has inhibitiory for dyn I GTPase with an IC50 value of 7.7 μM[1].

  • CAS Number: 2650733-69-8
  • MF: C17H18Br2N2O
  • MW: 426.15
  • Catalog: Dynamin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Dynasore

Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 μM.

  • CAS Number: 304448-55-3
  • MF: C18H14N2O4
  • MW: 322.315
  • Catalog: Dynamin
  • Density: 1.36±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Drp1-IN-1

Drp1-IN-1 (comp A-7) is a dynamin-1-like protein (Drp1) inhibitor, with an IC50 of 0.91 μM[1].

  • CAS Number: 2247733-08-8
  • MF: C22H24N8OS
  • MW: 448.54
  • Catalog: Dynamin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Dynapyrazole-A

Dynapyrazole A is a specific inhibitor of microtubule dynamin that specifically inhibits the ATPase activity of microtubule-stimulated dynamin without blocking microtubule-independent basal activity[1].

  • CAS Number: 2226517-75-3
  • MF: C20H12ClIN4O
  • MW: 486.7
  • Catalog: Dynamin
  • Density: 1.9±0.1 g/cm3
  • Boiling Point: 551.3±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 287.2±30.1 °C

2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide

Hydroxy Dynasore (Dyngo-4a), a structural analog of Dynasore (HY-15304), is an potency improved, low cytotoxicity and non‐specific binding dynamin inhibitor with IC50 values of 0.38 μM and 2.3 μM for brain dynamin I and recombinant rat dynamin II, respectively. Hydroxy Dynasore inhibits dynamin‐dependent endocytosis of transferrin with an IC50 of 5.7 μM in vitro.

  • CAS Number: 1256493-34-1
  • MF: C18H14N2O5
  • MW: 338.314
  • Catalog: Dynamin
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Dynamin IN-2

Dynamin IN-2 (compound 43), a Wiskostatin (HY-12534) analogue, is a potent dynamin inhibitor, with an IC50 of 1.0 μM for dynamin I GTPase. Dynamin IN-2 also blocks clathrin mediated endocytosis (CME), with an IC50 of 9.5 μM[1].

  • CAS Number: 1345853-49-7
  • MF: C22H21ClN2O
  • MW: 364.87
  • Catalog: Dynamin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

DRP1i27

DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury[1].

  • CAS Number: 1453028-33-5
  • MF: C20H26N6O
  • MW: 366.46
  • Catalog: Dynamin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Clathrin-IN-4

Clathrin-IN-4 (compound 8b), a Wiskostatin (HY-12534) analogue, is a potent inhibitor of clathrin mediated endocytosis with an IC50 of 2.1 μM. Clathrin-IN-4 is a dynamin I GTPase activity inhibitor with an IC50 of 9.1 μM[1].

  • CAS Number: 762242-59-1
  • MF: C17H18Br2N2O
  • MW: 426.15
  • Catalog: Dynamin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Octadecyltrimethylammonium bromide

Trimethyloctadecylammonium bromide is an inhibitor of dynamin, with an IC50 value of 1.9 μM for dynamin I. Trimethyloctadecylammonium bromide exhibits antibacterial activity against Staphylococcus aureus[1][2].

  • CAS Number: 1120-02-1
  • MF: C21H46BrN
  • MW: 392.501
  • Catalog: Dynamin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: ~250 °C (dec.)(lit.)
  • Flash Point: N/A

MB 0223

MB-0223 is a potent and selective dynamin-related GTPase Drp1 partial inhibitor (IC50=1.3 μM) over other dynamin family members, Opa 1 and dynamin-1 (IC50>100 μM)[1].

  • CAS Number: 2247732-89-2
  • MF: C26H27N5OS
  • MW: 457.59
  • Catalog: Dynamin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

DynaMin inhibitory peptide, myristoylated

DynaMin inhibitory peptide, myristoylated is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated is a membrane-permeant form of the peptide that prevents endocytosis[1].

  • CAS Number: 251634-22-7
  • MF: C61H107N19O14
  • MW: 1330.62000
  • Catalog: Dynamin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Dynamin inhibitory peptide

Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors[1].

  • CAS Number: 251634-21-6
  • MF: C47H80N18O14
  • MW: 1121.25000
  • Catalog: Dynamin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Dynole 2−24

Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis

  • CAS Number: 1416313-72-8
  • MF: C24H41N3
  • MW: 371.60
  • Catalog: Dynamin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Mdivi-1

Mdivi-1 is a selective dynamin-related protein 1 (Drp1) inhibitor.

  • CAS Number: 338967-87-6
  • MF: C15H10Cl2N2O2S
  • MW: 353.223
  • Catalog: Dynamin
  • Density: 1.6±0.1 g/cm3
  • Boiling Point: 522.5±60.0 °C at 760 mmHg
  • Melting Point: 289 °C
  • Flash Point: 269.8±32.9 °C

Schaftoside

Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission[1].

  • CAS Number: 51938-32-0
  • MF: C26H28O14
  • MW: 564.49
  • Catalog: Dynamin
  • Density: 1.8±0.1 g/cm3
  • Boiling Point: 1028.2±65.0 °C at 760 mmHg
  • Melting Point: 228ºC
  • Flash Point: 342.7±27.8 °C