组织蛋白酶D 来源于牛脾脏结构式
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常用名 | 组织蛋白酶D 来源于牛脾脏 | 英文名 | Cathepsin D, from bovine spleen |
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CAS号 | 9025-26-7 | 分子量 | 276.351 | |
密度 | 1.3±0.1 g/cm3 | 沸点 | 432.4±45.0 °C at 760 mmHg | |
分子式 | C15H16O3S | 熔点 | N/A | |
MSDS | 中文版 美版 | 闪点 | 215.3±28.7 °C |
组织蛋白酶D 来源于牛脾脏用途组织蛋白酶D(CTSD)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。 |
中文名 | 生化酶 |
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英文名 | cathepsin d |
英文别名 | 更多 |
密度 | 1.3±0.1 g/cm3 |
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沸点 | 432.4±45.0 °C at 760 mmHg |
分子式 | C15H16O3S |
分子量 | 276.351 |
闪点 | 215.3±28.7 °C |
精确质量 | 276.082001 |
LogP | 3.16 |
外观性状 | 冻干粉 |
蒸汽压 | 0.0±1.1 mmHg at 25°C |
折射率 | 1.609 |
储存条件 | -20°C密闭,避光,通风干燥处 |
稳定性 | Unit Definition One unit will produce an increase in A280 of 1.0 per min per mL at pH 3.0 at 37 °C measured as TCA-soluble products using hemoglobin as substrate (1 cm light path). Physical form Lyophilized powder containing citrate buffer salts Biochem/physiol Actions Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer’s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced. |
计算化学 | 1.疏水参数计算参考值(XlogP):2.7 2.氢键供体数量:1 3.氢键受体数量:4 4.可旋转化学键数量:3 5.互变异构体数量:3 6.拓扑分子极性表面积79.7 7.重原子数量:19 8.表面电荷:0 9.复杂度:427 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:2 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1 |
更多 | 1. 性状: 白色冻干粉末。 2. 密度(g/mL,25℃):未确定 3. 相对蒸汽密度(g/mL,空气=1):未确定 4. 熔点(ºC):未确定 5. 沸点(ºC,常压):未确定 6. 沸点(ºC,5.2kPa):未确定 7. 折射率:未确定 8. 闪点(ºC):未确定 9. 比旋光度(º):未确定 10. 自燃点或引燃温度(ºC):未确定 11. 蒸气压(kPa,20ºC):未确定 12. 饱和蒸气压(kPa,60ºC):未确定 13. 燃烧热(KJ/mol):未确定 14. 临界温度(ºC):未确定 15. 临界压力(KPa):未确定 16. 油水(辛醇/水)分配系数的对数值:未确定 17. 爆炸上限(%,V/V):未确定 18. 爆炸下限(%,V/V):未确定 19. 溶解性:溶于水 |
危险品运输编码 | NONH for all modes of transport |
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4-tert-Octylphenol stimulates the expression of cathepsins in human breast cancer cells and xenografted breast tumors of a mouse model via an estrogen receptor-mediated signaling pathway.
Toxicology 304 , 13-20, (2013) Endocrine disrupting chemicals (EDCs) are defined as environmental compounds that modulate steroid hormone receptor-dependent responses an abnormal manner, resulting in adverse health problems for hum... |
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A periodate-cleavable linker for functional proteomics under slightly acidic conditions: application for the analysis of intracellular aspartic proteases.
J. Proteome Res. 12(1) , 199-207, (2013) Specific elution of captured proteins greatly improves the quality of proteomic data obtained from pull-downs by avoiding signals from nonspecific proteins, thus allowing more sensitive identification... |
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Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release.
Cell Death Dis. 4 , e507, (2013) Colorectal carcinoma (CRC) is one of the most common causes of cancer-related mortality. Short-chain fatty acids secreted by dietary propionibacteria from the intestine, such as acetate, induce apopto... |
2-[(3-Hydroxy-2-butanyl)sulfanyl]-3-methyl-1,4-naphthoquinone |
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MFCD00130749 |