Palbociclib-propargyl

Modify Date: 2024-01-15 18:07:41

Palbociclib-propargyl structure	Common Name	Palbociclib-propargyl
	CAS Number	2366269-23-8	Molecular Weight	485.58
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₁N₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Palbociclib-propargyl

Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1].

Name	Palbociclib-propargyl

Description	Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582.

Molecular Formula	C₂₇H₃₁N₇O₂
Molecular Weight	485.58
Storage condition	-20°C