FC-11

Modify Date: 2024-01-15 11:54:32

FC-11 structure	Common Name	FC-11
	CAS Number	2271035-37-9	Molecular Weight	949.91
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₁H₄₂F₃N₁₃O₉S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FC-11

FC-11 is a PROTAC FAK degrader (DC90: 1 nM) . FC-11 contains CRBN ligand Pomalidomide (HY-10984), linker and FAK ligand PF562271 (HY-10459). FC-11 degrades FAK in various cells, with DC50s of 310 pM in TM3, 80 pM in PA1, 330 pM in MDA-MB-436, 370 pM in LNCaP, and 40 pM in Ramos cells[1].

Name	FC-11

Description	FC-11 is a PROTAC FAK degrader (DC90: 1 nM) . FC-11 contains CRBN ligand Pomalidomide (HY-10984), linker and FAK ligand PF562271 (HY-10459). FC-11 degrades FAK in various cells, with DC50s of 310 pM in TM3, 80 pM in PA1, 330 pM in MDA-MB-436, 370 pM in LNCaP, and 40 pM in Ramos cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK Signaling Pathways >> PROTAC >> PROTAC
References	[1]. Gao H, et al. Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs. ACS Med Chem Lett. 2019 Oct 22;11(10):1855-1862. Gao H, Wu Y, Sun Y, Yang Y, Zhou G, Rao Y. Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs. ACS Med Chem Lett. 2019 Oct 22;11(10):1855-1862.

Molecular Formula	C₄₁H₄₂F₃N₁₃O₉S
Molecular Weight	949.91

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FC-11

Use of FC-11

Names

FC-11 Biological Activity

Chemical & Physical Properties