Cosalane

Modify Date: 2024-04-02 17:31:59

Cosalane structure	Common Name	Cosalane
	CAS Number	154212-56-3	Molecular Weight	767.86000
	Density	1.191g/cm3	Boiling Point	797.4ºC at 760mmHg
	Molecular Formula	C₄₅H₆₀Cl₂O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	436.1ºC

Use of Cosalane

Cosalane (NSC 658586) is a potent inhibitor of HIV replication. Cosalane has an intrinsic ability to block human and murine CCR7 function in vitro in response to both of its natural ligands, CCL19 and CCL21, with the IC50 of 0.207/2.66 μM in human for CCL19/CCL21 and 0.193/1.98 μM in murine, respectively[1][2].

Name	5-[1-(3-carboxy-5-chloro-4-hydroxyphenyl)-4-[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]but-1-enyl]-3-chloro-2-hydroxybenzoic acid
Synonym	More Synonyms

Description	Cosalane (NSC 658586) is a potent inhibitor of HIV replication. Cosalane has an intrinsic ability to block human and murine CCR7 function in vitro in response to both of its natural ligands, CCL19 and CCL21, with the IC50 of 0.207/2.66 μM in human for CCL19/CCL21 and 0.193/1.98 μM in murine, respectively[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CCR Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Immunology/Inflammation >> CCR
Target	Human CCR7 Murine CCR7
References	[1]. Kenneth A Fowler, et al. The Ex Vivo Treatment of Donor T Cells with Cosalane, an HIV Therapeutic and Small-Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplantation Models. Biol Blood Marrow Transplant. 2019 Jun;25(6):1062-1074. [2]. Emily A Hull-Ryde, et al. Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen. SLAS Discov. 2018 Dec;23(10):1083-1091.

Density	1.191g/cm3
Boiling Point	797.4ºC at 760mmHg
Molecular Formula	C₄₅H₆₀Cl₂O₆
Molecular Weight	767.86000
Flash Point	436.1ºC
Exact Mass	766.37700
PSA	115.06000
LogP	12.75040
Vapour Pressure	7.99E-27mmHg at 25°C