PyrazinaMide-d3

Modify Date: 2024-01-08 15:46:03

PyrazinaMide-d3 structure	Common Name	PyrazinaMide-d3
	CAS Number	1432059-16-9	Molecular Weight	126.13
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅H₂D₃N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PyrazinaMide-d3

Pyrazinamide-d3 is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a prodrug that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis[1][2].

Name	PyrazinaMide-d3

Description	Pyrazinamide-d3 is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a prodrug that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Y Zhang, et al. Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J Bacteriol. 1999 Apr;181(7):2044-9. [3]. Ying Zhang, et al. Mechanisms of Pyrazinamide Action and Resistance. Microbiol Spectr. 2014 Aug;2(4):MGM2-0023-2013.

Molecular Formula	C₅H₂D₃N₃O
Molecular Weight	126.13

PyrazinaMide-d3

Use of PyrazinaMide-d3

Names

PyrazinaMide-d3 Biological Activity

Chemical & Physical Properties