[3-(quinolin-2-ylmethoxy)phenyl]methanol
Modify Date: 2024-01-09 13:17:45
![[3-(quinolin-2-ylmethoxy)phenyl]methanol Structure](https://www.chemsrc.com/caspic/110/123226-28-8.png)
[3-(quinolin-2-ylmethoxy)phenyl]methanol structure
|
Common Name | [3-(quinolin-2-ylmethoxy)phenyl]methanol | ||
|---|---|---|---|---|
| CAS Number | 123226-28-8 | Molecular Weight | 265.30700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H15NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of [3-(quinolin-2-ylmethoxy)phenyl]methanolCAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC50=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC50=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1]. |
| Name | [3-(quinolin-2-ylmethoxy)phenyl]methanol |
|---|---|
| Synonym | More Synonyms |
| Description | CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC50=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC50=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1]. |
|---|---|
| Related Catalog | |
| Target |
CysLT1:2.80 ± 0.3 μM (IC50) TNF-α |
| References |
| Molecular Formula | C17H15NO2 |
|---|---|
| Molecular Weight | 265.30700 |
| Exact Mass | 265.11000 |
| PSA | 42.35000 |
| LogP | 3.30610 |
| 3-(2-quinolinylmethyloxy)benzyl alcohol |
| 2-(3-hydroxymethylphenoxy)methylquinoline |
| 3-(2-quinolinylmethoxy)benzyl alcohol |
| 3-(quinol-2-ylmethoxy)benzyl alcohol |
| 3-(Quinolin-2-ylmethoxy)benzyl alcohol |
| [3-(quinolin-2-ylmethoxy)-phenyl]-methanol |
| Benzenemethanol,3-(2-quinolinylmethoxy) |