6-Geranylnaringenin
Modify Date: 2024-01-16 20:37:56
6-Geranylnaringenin structure
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Common Name | 6-Geranylnaringenin | ||
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| CAS Number | 97126-57-3 | Molecular Weight | 408.48682 | |
| Density | 1.219±0.06 g/cm3 | Boiling Point | 647.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C25H28O5 | Melting Point | 116-118 °C | |
| MSDS | N/A | Flash Point | N/A | |
Use of 6-GeranylnaringeninBonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 14 µM. Bonannione A triggers caspase-dependent Apoptosis. Bonannione A induces Autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity[1][2][3]. |
| Name | 6-Geranylnaringenin |
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| Description | Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 14 µM. Bonannione A triggers caspase-dependent Apoptosis. Bonannione A induces Autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity[1][2][3]. |
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| Related Catalog | |
| In Vitro | 6-香叶草基柚皮素 (0-80 µM; 12, 24 小时) 在癌细胞系中以剂量和时间依赖性方式显着抑制细胞增殖[2]。 6-香叶草基柚皮素 (0-60 µM; 24 小时) 在 A549 细胞中触发半胱天冬酶依赖性细胞凋亡。6-香叶草基柚皮素增加凋亡亚 G1 期细胞的积累和 G2/M 期细胞的数量[2]。 6-香叶草基柚皮素 (60 µM; 24 小时) 在 A549 细胞中触发自噬而不损害自噬通量[2]。 6-香叶草基柚皮素 (60 µM; 24 小时) 显着降低 p53 和磷酸化 mTOR 的水平[2]。 Cell Proliferation Assay[2] Cell Line: Human lung cancer A549, breast cancer MCF-7, colon cancer HCT116 and osteosarcoma U2OS cells Concentration: 20, 40, 60, 80 µM Incubation Time: 12, 24 h Result: Significantly inhibited cell proliferation in a dose- and time-dependent way in these cancer cell lines. Apoptosis Analysis[2] Cell Line: A549 cells Concentration: 0-60 µM Incubation Time: 24 h Result: Annexin V/PI-positive cells were markedly increased in a dose- and time-dependent way. Induced apoptosis through caspase-3 activation and PARP cleavage. Cell Cycle Analysis[2] Cell Line: A549 cells Concentration: 0-60 µM Incubation Time: 24 h Result: Increased accumulation of cells at the apoptotic sub-G1 phase in a dose-dependent manner. The number of cells at G2/M phase also increased in a dose-dependent manner. Cell Autophagy Assay[2] Cell Line: A549 cells Concentration: 60 µM Incubation Time: 24 h Result: Remarkably increased ATG7 and LC3-II protein levels in a dose-dependent way, but Beclin-1 level was slightly augmented. Western Blot Analysis[2] Cell Line: A549 cells Concentration: 60 µM Incubation Time: 0-24 h Result: Remarkably decreased the levels of p53 and phospho-mTOR. Significantly increased whereas the levels of phospho-AMPK and phospho-Acetyl-CoA Carboxylase (ACC), an AMPK substrate. |
| In Vivo | 6-香叶草基柚皮素 (25 mg/kg; 灌胃; DSS 前 48 和 24 小时，随后每 24 小时一次; 持续 5 天) 改善结肠炎的症状并延迟其发作[3]。 Animal Model: Male Wistar rats (180-220 g)[3] Dosage: 25 mg/kg Administration: Gavage; 48 and 24 h prior to DSS (10% (w/v)) and every 24 h on the following days; for 5days Result: Ameliorated the symptoms of colitis and delayed their onset. Showed the low DAI on the last day of the experiment. |
| References |
| Density | 1.219±0.06 g/cm3 |
|---|---|
| Boiling Point | 647.8±55.0 °C at 760 mmHg |
| Melting Point | 116-118 °C |
| Molecular Formula | C25H28O5 |
| Molecular Weight | 408.48682 |