γ-Fibrinogen 377-395
Modify Date: 2025-08-25 09:28:16
γ-Fibrinogen 377-395 structure
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Common Name | γ-Fibrinogen 377-395 | ||
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| CAS Number | 957792-67-5 | Molecular Weight | 2229.66 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C100H165N25O28S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of γ-Fibrinogen 377-395γ-Fibrinogen377-395 is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation[1]. |
| Name | γ-Fibrinogen 377-395 |
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| Description | γ-Fibrinogen377-395 is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation[1]. |
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| Related Catalog | |
| In Vitro | γ-Fibrinogen377-395 (200 μM) 阻断纤维蛋白与 Mac-1 的结合，从而抑制 Mac-1 过表达细胞与固定化纤维蛋白原的粘附。γ-Fibrinogen377-395 抑制小胶质细胞活化[1]。 |
| In Vivo | γ-Fibrinogen377-395 (30 μg/小鼠；鼻内给药；每天一次，持续 40 天) 增加小鼠的运动功能而不影响外周免疫反应。 γ-纤维蛋白原377-395不影响纤维蛋白原的凝血特性[1]。 在 EAE 诱导前用 γ377-395 肽免疫接种 γ377-395 肽的小鼠，与对照组相比，运动强度和协调性有所提高[1]。 Animal Model: PLP139-151-immunized mice with experimental autoimmune encephalomyelitis (EAE)[1] Dosage: 30 μg/mouse Administration: Administered intranasally; daily after the first paralytic episode in remitting relapsing EAE Result: Reduced the progression and severity of EAE by specifically targeting microglia/macrophage activation in the CNS parenchyma without adverse hemorrhagic effects. |
| References |
| Molecular Formula | C100H165N25O28S2 |
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| Molecular Weight | 2229.66 |