γ-Fibrinogen 377-395

Modify Date: 2024-01-02 22:12:53

γ-Fibrinogen 377-395 Structure
γ-Fibrinogen 377-395 structure
 Common Name γ-Fibrinogen 377-395
CAS Number 957792-67-5 Molecular Weight 2229.66
Density N/A Boiling Point N/A
Molecular Formula C100H165N25O28S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of γ-Fibrinogen 377-395


γ-Fibrinogen377-395 is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation[1].

 Names

Name γ-Fibrinogen 377-395

 γ-Fibrinogen 377-395 Biological Activity

Description γ-Fibrinogen377-395 is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation[1].
Related Catalog
In Vitro γ-Fibrinogen377-395 (200 μM) 阻断纤维蛋白与 Mac-1 的结合，从而抑制 Mac-1 过表达细胞与固定化纤维蛋白原的粘附。γ-Fibrinogen377-395 抑制小胶质细胞活化[1]。
In Vivo γ-Fibrinogen377-395 (30 μg/小鼠；鼻内给药；每天一次，持续 40 天) 增加小鼠的运动功能而不影响外周免疫反应。 γ-纤维蛋白原377-395不影响纤维蛋白原的凝血特性[1]。 在 EAE 诱导前用 γ377-395 肽免疫接种 γ377-395 肽的小鼠，与对照组相比，运动强度和协调性有所提高[1]。 Animal Model: PLP139-151-immunized mice with experimental autoimmune encephalomyelitis (EAE)[1] Dosage: 30 μg/mouse Administration: Administered intranasally; daily after the first paralytic episode in remitting relapsing EAE Result: Reduced the progression and severity of EAE by specifically targeting microglia/macrophage activation in the CNS parenchyma without adverse hemorrhagic effects.
References

[1]. Adams RA, et al. The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med. 2007 Mar 19;204(3):571-82.  

 Chemical & Physical Properties

Molecular Formula C100H165N25O28S2
Molecular Weight 2229.66
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