Isofagomine D-Tartrate
Modify Date: 2025-08-25 10:25:06
Isofagomine D-Tartrate structure
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Common Name | Isofagomine D-Tartrate | ||
|---|---|---|---|---|
| CAS Number | 957230-65-8 | Molecular Weight | 297.26 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H19NO9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Isofagomine D-TartrateAfegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1]. |
| Name | Afegostat |
|---|---|
| Synonym | More Synonyms |
| Description | Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1]. |
|---|---|
| Related Catalog | |
| Target |
GCase[1] |
| In Vivo | Vivo: Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates[1]. |
| References |
| Molecular Formula | C10H19NO9 |
|---|---|
| Molecular Weight | 297.26 |
| Exact Mass | 297.105988 |
| Storage condition | 2-8℃ |
| Isofagomine D-Tartrate |
| Butanedioic acid, 2,3-dihydroxy-, (2S,3S)-, compd. with (3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol (1:1) |
| (2S,3S)-2,3-Dihydroxysuccinic acid - (3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol (1:1) |
| (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol (2S,3S)-2,3-Dihydroxybutanedioate |
| Afegostat (D-Tartrate) |