3MB-PP1

Modify Date: 2025-08-25 14:36:46

3MB-PP1 structure	Common Name	3MB-PP1
	CAS Number	956025-83-5	Molecular Weight	295.38200
	Density	1.209g/cm3	Boiling Point	475.471ºC at 760 mmHg
	Molecular Formula	C₁₇H₂₁N₅	Melting Point	136-138ºC
	MSDS	N/A	Flash Point	241.356ºC

Use of 3MB-PP1

3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 (Plk1) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 μM). 3MB-PP1 can be used for the research of hypha formation of Candida albicans and cell division[1][2][3].

Name	1-tert-butyl-3-[(3-methylphenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-amine
Synonym	More Synonyms

Description	3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 (Plk1) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 μM). 3MB-PP1 can be used for the research of hypha formation of Candida albicans and cell division[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Apoptosis >> DAPK Signaling Pathways >> Cell Cycle/DNA Damage >> Polo-like Kinase (PLK) Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	Leu93-ZIPK:2 μM (IC50)
In Vitro	3MB-PP1 (5 μM; 3 hours) stimulates hyphal growth in a strain bearing analog-sensitive alleles of SSN3[1].
References	[1]. Burkard ME, et al. Enabling and disabling polo-like kinase 1 inhibition through chemical genetics. ACS Chem Biol. 2012 Jun 15;7(6):978-81. [2]. Hollomon JM, et al. The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway. PLoS Genet. 2022;18(1):e1009622. Published 2022 Jan 4. [3]. Al-Ghabkari A, et al. Validation of chemical genetics for the study of zipper-interacting protein kinase signaling. Proteins. 2018 Nov;86(11):1211-1217.

Density	1.209g/cm3
Boiling Point	475.471ºC at 760 mmHg
Melting Point	136-138ºC
Molecular Formula	C₁₇H₂₁N₅
Molecular Weight	295.38200
Flash Point	241.356ºC
Exact Mass	295.18000
PSA	69.62000
LogP	3.64390
Index of Refraction	1.64
InChIKey	FYCOTGCSHZKHPR-UHFFFAOYSA-N
SMILES	Cc1cccc(Cc2nn(C(C)(C)C)c3ncnc(N)c23)c1

2wei

VGG

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 3MB-PP1
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: 3-MB-PP1
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Get all suppliers and price by the below link:

3MB-PP1 suppliers

3MB-PP1 price

3MB-PP1

Use of 3MB-PP1

Names

3MB-PP1 Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.