PF-429242

Modify Date: 2025-09-19 17:59:19

Use of PF-429242

PF429242 is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM[1].

Name	(R)-4-((Diethylamino)methyl)-N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)benzamide
Synonym	More Synonyms

Description	PF429242 is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS) Research Areas >> Infection Research Areas >> Metabolic Disease
References	[1]. Hawkins JL, et al. Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals. J Pharmacol Exp Ther. 2008 Sep;326(3):801-8. [2]. Uchida L, et al. Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation. Viruses. 2016 Feb 10;8(2). pii: E46. [3]. Urata S, et al. Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. J Virol. 2011 Jan;85(2):795-803.

Description

PF429242 is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM[1].

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS)

Research Areas >> Infection

Research Areas >> Metabolic Disease

References

Density	1.1±0.1 g/cm3
Boiling Point	562.2±50.0 °C at 760 mmHg
Molecular Formula	C₂₅H₃₅N₃O₂
Molecular Weight	409.56
Flash Point	293.8±30.1 °C
Exact Mass	409.272919
PSA	44.81000
LogP	2.88
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.586
InChIKey	XKPJTOHUPQWSOJ-HSZRJFAPSA-N
SMILES	CCN(CC)Cc1ccc(C(=O)N(CCc2ccccc2OC)C2CCNC2)cc1
Storage condition	-20℃

PF-429242 MSDS(Chinese)

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-[(diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide

4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-3-pyrrolidinyl]benzamide

Benzamide, 4-[(diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-3-pyrrolidinyl]-

4-(diethylaminomethyl)-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide

PF-429242

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (R)-4-((DIETHYLAMINO)METHYL)-N-(2-METHOXYPHENETHYL)-N-(PYRROLIDIN-3-YL)BENZAMIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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