Ontuxizumab
Modify Date: 2024-01-15 19:27:08
Ontuxizumab structure
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Common Name | Ontuxizumab | ||
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| CAS Number | 946415-62-9 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of OntuxizumabOntuxizumab (MORAb-004) is a humanized IgG1/κ anti-endosialin (TEM-1 or CD248) monoclonal antibody with antitumor effects. Ontuxizumab can be used for the research of cancer[1]. |
| Name | Ontuxizumab |
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| Description | Ontuxizumab (MORAb-004) is a humanized IgG1/κ anti-endosialin (TEM-1 or CD248) monoclonal antibody with antitumor effects. Ontuxizumab can be used for the research of cancer[1]. |
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| Related Catalog | |
| In Vitro | Ontuxizumab (0-100 μg/mL；12 小时) 诱导 CD248 内化并剂量依赖性地降低了 46% 的人周皮细胞表面的 CD248[1]。 |
| In Vivo | Ontuxizumab (50 mg/kg；静脉注射，每天 5 次，连续 5 天) 在人 CD248 敲入小鼠显示抗肿瘤作用[1]。 Animal Model: Human CD248 knock-in mice[1] Dosage: 50 mg/kg Administration: Intravenous injection via tail vein; 50 mg/kg, 5 doses daily for 5 consecutive days Result: Reduced tumor growth with a lower level of CD248 and α-SMA on neovasculature pericytes. |
| References |
| No Any Chemical & Physical Properties |