Pexmetinib structure
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Common Name | Pexmetinib | ||
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CAS Number | 945614-12-0 | Molecular Weight | 556.630 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | 694.1±55.0 °C at 760 mmHg | |
Molecular Formula | C31H33FN6O3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 373.6±31.5 °C |
Use of PexmetinibPexmetinib is a potent Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia. |
Name | 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[[5-fluoro-2-[1-(2-hydroxyethyl)indazol-5-yl]oxyphenyl]methyl]urea |
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Synonym | More Synonyms |
Description | Pexmetinib is a potent Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia. |
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Related Catalog | |
Target |
IC50: 1 nM (Tie-2), 35 nM (p38α), 26 nM (p38β)[1] |
In Vitro | Pexmetinib is a Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively. Pexmetinib also shows IC50s of 4 nM (Abl), 10 nM (Arg), 28 nM (FGFR1), 47 nM (Flt1), 42 nM (Flt4), 41 nM (Fyn), 26 nM (Hck), 25 nM (Lyn), and 26 nM (MINK), respectively. Pexmetinib (0.5, 1 μM) blocks leukemic cell proliferation and stimulates hematopoietic activity in myelodysplastic syndromes[1]. |
Cell Assay | Cell lines and primary samples are incubated at indicated doses of of TIE2/p38 inhibitor Pexmetinib. Viability is assessed by addition of Cell Titer Blue and measured via Fluostar Omega Microplate reader[1]. |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 694.1±55.0 °C at 760 mmHg |
Molecular Formula | C31H33FN6O3 |
Molecular Weight | 556.630 |
Flash Point | 373.6±31.5 °C |
Exact Mass | 556.259827 |
PSA | 109.72000 |
LogP | 6.81 |
Vapour Pressure | 0.0±2.3 mmHg at 25°C |
Index of Refraction | 1.635 |
Storage condition | -20℃ |
ARRY-614 |
pexmétinib |
pexmetinib |
1-(5-Fluoro-2-{[1-(2-hydroxyethyl)-1H-indazol-5-yl]oxy}benzyl)-3-[1-(4-methylphenyl)-3-(2-methyl-2-propanyl)-1H-pyrazol-5-yl]urea |
Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[[5-fluoro-2-[[1-(2-hydroxyethyl)-1H-indazol-5-yl]oxy]phenyl]methyl]- |
UNII-3750D0U8B5 |