Ezutromid
Modify Date: 2024-01-02 13:19:59
Ezutromid structure
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Common Name | Ezutromid | ||
|---|---|---|---|---|
| CAS Number | 945531-77-1 | Molecular Weight | 337.39200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H15NO3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EzutromidEzutromid is a novel Small utrophin's translation modulator with EC50 of 0.4 uM .In vitro: 1) SMT C1100 induces increased levels of utrophin RNA in human muscle cells.2) Treatment of human DMD cells with SMT C1100 lead to a 2-fold increase in utrophin protein levels at an optimal concentration of 0.3 uM after 3 days of treatment. 3) SMT C1100 wassafe and well tolerated with plasma concentrations achieved suf?cient to cause a 50% increase in concentrations of utrophin in cells. 4) SMT C1100 led to a 30% increase in Utrn mRNA level and resulted in a 2.0-fold increase in UTRN protein level .In vivo: 1)The reference for administration is 50 mg/kg. 2) it was considered that no toxicity was determined for SMT C1100 administered by oral gavage to the mouse up to dose levels of 2000 mg/kg/day for 28 days.Note: You can dissolve the products in phosphate buffered saline (PBS), 0.1% Tween-20, 5% DMSO) |
| Name | 5-ethylsulfonyl-2-naphthalen-2-yl-1,3-benzoxazole |
|---|---|
| Synonym | More Synonyms |
| Description | Ezutromid is a novel Small utrophin's translation modulator with EC50 of 0.4 uM .In vitro: 1) SMT C1100 induces increased levels of utrophin RNA in human muscle cells.2) Treatment of human DMD cells with SMT C1100 lead to a 2-fold increase in utrophin protein levels at an optimal concentration of 0.3 uM after 3 days of treatment. 3) SMT C1100 wassafe and well tolerated with plasma concentrations achieved suf?cient to cause a 50% increase in concentrations of utrophin in cells. 4) SMT C1100 led to a 30% increase in Utrn mRNA level and resulted in a 2.0-fold increase in UTRN protein level .In vivo: 1)The reference for administration is 50 mg/kg. 2) it was considered that no toxicity was determined for SMT C1100 administered by oral gavage to the mouse up to dose levels of 2000 mg/kg/day for 28 days.Note: You can dissolve the products in phosphate buffered saline (PBS), 0.1% Tween-20, 5% DMSO) |
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| Related Catalog | |
| References |
| Molecular Formula | C19H15NO3S |
|---|---|
| Molecular Weight | 337.39200 |
| Exact Mass | 337.07700 |
| PSA | 68.55000 |
| LogP | 5.52240 |
| Storage condition | 2-8℃ |
| UNII-645R07LF0D |
| BMN 195 |
| SMT c1100 |
| Ezutromid |