Amiselimod hydrochloride
Modify Date: 2024-01-05 18:19:39
Amiselimod hydrochloride structure
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Common Name | Amiselimod hydrochloride | ||
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| CAS Number | 942398-84-7 | Molecular Weight | 413.902 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H31ClF3NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Amiselimod hydrochlorideAmiselimod hydrochloride is a novel sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators.target: S1P1In vivo: After oral administration of amiselimod or fingolimod at 1 mg/kg, the concentration of amiselimod-P in rat heart tissue was relatively lower than that of fingolimod-P, potentially contributing to the minimal cardiac effects of amiselimod. Amiselimod-P showed potent selectivity for S1P1 , high selectivity for S1P5 , minimal agonist activity for S1P4 , no distinct agonist activity for S1P2 or S1P3 , and approximately 5-fold weaker GIRK activation than fingolimod-P. [1] Amiselimod 0·2 mg and 0·4 mg significantly reduced the total number of gadolinium-enhanced T1-weighted lesions. [2] |
| Name | amiselimod hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Amiselimod hydrochloride is a novel sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators.target: S1P1In vivo: After oral administration of amiselimod or fingolimod at 1 mg/kg, the concentration of amiselimod-P in rat heart tissue was relatively lower than that of fingolimod-P, potentially contributing to the minimal cardiac effects of amiselimod. Amiselimod-P showed potent selectivity for S1P1 , high selectivity for S1P5 , minimal agonist activity for S1P4 , no distinct agonist activity for S1P2 or S1P3 , and approximately 5-fold weaker GIRK activation than fingolimod-P. [1] Amiselimod 0·2 mg and 0·4 mg significantly reduced the total number of gadolinium-enhanced T1-weighted lesions. [2] |
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| Related Catalog | |
| References |
| Molecular Formula | C19H31ClF3NO3 |
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| Molecular Weight | 413.902 |
| Exact Mass | 413.194458 |
| Storage condition | 2-8℃ |
| MT-1303 |
| UNII-AY898D6RU1 |
| AMISELIMOD HYDROCHLORIDE |
| 2-Amino-2-{2-[4-(heptyloxy)-3-(trifluorométhyl)phényl]éthyl}-1,3-propanediol, chlorhydrate (1:1) |
| 2-Amino-2-{2-[4-(heptyloxy)-3-(trifluormethyl)phenyl]ethyl}-1,3-propandiolhydrochlorid (1:1) |
| 2-Amino-2-{2-[4-(heptyloxy)-3-(trifluoromethyl)phenyl]ethyl}-1,3-propanediol hydrochloride (1:1) |
| 1,3-Propanediol, 2-amino-2-[2-[4-(heptyloxy)-3-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1) |
| Amiselimod HCl |