Cicaprost

Modify Date: 2024-01-11 10:56:58

Cicaprost structure	Common Name	Cicaprost
	CAS Number	94079-80-8	Molecular Weight	374.471
	Density	1.2±0.1 g/cm3	Boiling Point	591.1±50.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₃₀O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	203.4±23.6 °C

Use of Cicaprost

Cicaprost (ZK 96480) is a prostacyclin receptor (IP) agonist. Cicaprost causes a concentration-dependent relaxation of the artery with an EC50 of 5.8 nM [1]。

Name	Cicaprost
Synonym	More Synonyms

Description	Cicaprost (ZK 96480) is a prostacyclin receptor (IP) agonist. Cicaprost causes a concentration-dependent relaxation of the artery with an EC50 of 5.8 nM [1]。
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
In Vitro	Cicaprost significantly reduces proliferation of human pulmonary artery smooth muscle cells (HPASMC) stimulated by fetal bovine serum (FBS). Cicaprost displays marked antiproliferative activity at 30 nM[2]. Cicaprost stimulates [3H]cyclic AMP production with EC50 values of 1.5-22 nM, and stimulates [3H]inositol phosphate production (EC50 values 49-457 nM) in all but the SK-N-SH cells[3]. Cell Proliferation Assay[2] Cell Line: HPASMC Concentration: 10 pM, 100 pM, 1 nM, 10 nM, 100 nM, 1 μM, and 10 μM Incubation Time: Result: Dose-dependently inhibited proliferation with an EC50 of 24.1 nM.
In Vivo	Cicaprost alters pain perception and inflammatory response in mice lacking prostacyclin receptor. Intravenous injection of Cicaprost (1 μg/kg) causes hypotension of ∼30 mm Hg in anaesthetized wild-type mice[4]. Animal Model: Wild-type (+/+) and IP−/− mice[4] Dosage: 1 μg/kg Administration: Intravenous injection Result: Caused hypotension of ∼30 mm Hg in anaesthetized wild-type mice, whereas there was no change in blood pressure in IP-deficient mice even at 10 μg/kg.
References	[1]. Nicole Ferko, et al. NO synergism with cicaprost in the canine pulmonary artery. BioPharm Journal ONLINE 2:2 (1998). [2]. Lucie H Clapp, et al. Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery. Am J Respir Cell Mol Biol. 2002 Feb;26(2):194-201. [3]. Kevin B S Chow, et al. Protein kinase A-dependent coupling of mouse prostacyclin receptors to Gi is cell-type dependent. Eur J Pharmacol. 2003 Aug 1;474(1):7-13. [4]. T Murata, et al. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature. 1997 Aug 14;388(6643):678-82.

Density	1.2±0.1 g/cm3
Boiling Point	591.1±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₀O₅
Molecular Weight	374.471
Flash Point	203.4±23.6 °C
Exact Mass	374.209320
PSA	86.99000
LogP	1.94
Vapour Pressure	0.0±3.8 mmHg at 25°C
Index of Refraction	1.569

Precursor 9
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DownStream 0

({(2E)-2-[5-Hydroxy-4-(3-hydroxy-4-methyl-1,6-nonadiyn-1-yl)hexahydro-2(1H)-pentalenylidene]ethyl}oxy)acetic acid

Acetic acid, 2-[[(2E)-2-[hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1,6-nonadiyn-1-yl)-2(1H)-pentalenylidene]ethyl]oxy]-

13,14-Didehydro-16,20-dimethyl-3-oxa-18,18,19,19-tetradehydro-6-carbaprostaglandin I2

DC Chemicals Limited
China
Product Name: Cicaprost
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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