| Description |
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1[1].
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| Related Catalog |
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| Target |
NLRP3 inflammasome
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| In Vivo |
JC2-11 (250 μg/鼠；腹腔注射；单剂量) 显著抑制了 C57BL/6 小鼠模型中非典型 (NC) 炎症小体中 caspase-1 (p20) 和 IL-1β 的释放，弱化了 NC 炎症小体的激活[1]。 Animal Model: C57BL/6 mice (8 weeks, female)[1]. Dosage: 250 μg/mouse. Administration: Intraperitoneal injection; single dose. Result: Exhibited inhibitory effect on NC inflammatory body.
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| References |
[1]. Lee G, et al, JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation. Sci Rep. 2022 Dec 28;12(1):22484.
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