QM31
Modify Date: 2025-08-22 19:15:38
QM31 structure
|
Common Name | QM31 | ||
|---|---|---|---|---|
| CAS Number | 937735-00-7 | Molecular Weight | 768.557 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C39H38Cl4N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of QM31QM31 (SVT016426, Apaf-1 inhibitor QM31) is a cytoprotective agent that inhibits the formation of the apoptosome (IC50=7.9 uM in vitro), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9; suppresses the Apaf-1-dependent intra-S-phase DNA damage checkpoint; QM31 can interfere with the two known functions of Apaf-1, namely apoptosome assembly/activation and intra-S-phase cell cycle arrest. |
| Name | QM31 |
|---|
| Description | QM31 (SVT016426, Apaf-1 inhibitor QM31) is a cytoprotective agent that inhibits the formation of the apoptosome (IC50=7.9 uM in vitro), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9; suppresses the Apaf-1-dependent intra-S-phase DNA damage checkpoint; QM31 can interfere with the two known functions of Apaf-1, namely apoptosome assembly/activation and intra-S-phase cell cycle arrest. |
|---|---|
| References | References 1. Mondragón L, et al. Apoptosis. 2009 Feb;14(2):182-90. 2. Mondragón L, et al. J Med Chem. 2008 Feb 14;51(3):521-9. 3. Malet G, et al. Cell Death Differ. 2006 Sep;13(9):1523-32. View Related Products by Target Apaf-1 |
| Molecular Formula | C39H38Cl4N4O4 |
|---|---|
| Molecular Weight | 768.557 |
| InChIKey | YSUHYGYGQFSKDT-UHFFFAOYSA-N |
| SMILES | NC(=O)CN(CCc1ccc(Cl)cc1Cl)C(=O)C1CC(=O)N(CCc2ccc(Cl)cc2Cl)CC(=O)N1CCC(c1ccccc1)c1ccccc1 |