H-Arg-Gly-Asp-Val-OH

Modify Date: 2024-01-01 22:58:24

H-Arg-Gly-Asp-Val-OH Structure
H-Arg-Gly-Asp-Val-OH structure
 Common Name H-Arg-Gly-Asp-Val-OH
CAS Number 93674-99-8 Molecular Weight 445.47100
Density 1.57g/cm3 Boiling Point 821.1ºC at 760 mmHg
Molecular Formula C17H31N7O7 Melting Point N/A
MSDS N/A Flash Point 450.4ºC

 Use of H-Arg-Gly-Asp-Val-OH


RGDV is a platelet aggregation inhibitor. RGDV inhibits platelet-dependent thrombus formation. RGDV is used for tumor recognition via the targeting effect[1][2].

 Names

Name (2S)-2-[[(2S)-2-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoic acid
Synonym More Synonyms

 H-Arg-Gly-Asp-Val-OH Biological Activity

Description RGDV is a platelet aggregation inhibitor. RGDV inhibits platelet-dependent thrombus formation. RGDV is used for tumor recognition via the targeting effect[1][2].
Related Catalog
In Vitro RGDV (25-100 nM; thrombus vessel model) selectively inhibits platelet-dependent thrombus formation and decreases the accumulation of both platelets and fibrin on the collagen substrate in a dose-response manner[1].
References

[1]. Cadroy Y, et, al. RGDV peptide selectively inhibits platelet-dependent thrombus formation in vivo. Studies using a baboon model. J Clin Invest. 1989 Sep;84(3):939-44.

[2]. Wang F, et, al. Preparation and biological evaluation of tumor-specific Ara-C liposomal preparations containing RGDV motif. J Pharm Sci. 2012 Dec;101(12):4559-68.

 Chemical & Physical Properties

Density 1.57g/cm3
Boiling Point 821.1ºC at 760 mmHg
Molecular Formula C17H31N7O7
Molecular Weight 445.47100
Flash Point 450.4ºC
Exact Mass 445.22800
PSA 249.82000
Index of Refraction 1.644

 Synonyms

Rgdv tetrapeptide
Arg-gly-asp-val
Arginyl-glycyl-aspartyl-valine
L-Arginylglycyl-L-alpha-Aspartyl-L-Valine
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