(E)-C-HDMAPP ammonium
Modify Date: 2024-03-09 11:46:40
(E)-C-HDMAPP ammonium structure
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Common Name | (E)-C-HDMAPP ammonium | ||
|---|---|---|---|---|
| CAS Number | 933030-60-5 | Molecular Weight | 311.210 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C6H14O7P2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (E)-C-HDMAPP ammonium(E)-C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E)-HDMAPP. (E)-C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release)[1][2]. |
| Name | (5-hydroxy-4-methylpent-3-enyl)-phosphonooxyphosphinic acid |
|---|
| Description | (E)-C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E)-HDMAPP. (E)-C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release)[1][2]. |
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| Related Catalog | |
| Target |
TNFRSF1A |
| In Vitro | (E)-C-HDMAPP (化合物 5E) (2 μM) 增加原代多克隆人 Vγ9Vδ2 T 细胞中的 TNF-α 释放水平，并具有刺激性生物活性[1]。 |
| In Vivo | (E)-C-HDMAPP (化合物 5E) (0.02-10 mg/kg；静脉注射；15 天) 显着增加食蟹猴模型中的 γδ 细胞[1]。 Animal Model: Nonhuman Primate Model in Cynomolgus[1] Dosage: 0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg, 5 mg/kg, and 10 mg/kg Administration: Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days Result: Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 5 mg/kg and 10 mg/kg. |
| References |
| Molecular Formula | C6H14O7P2 |
|---|---|
| Molecular Weight | 311.210 |
| Exact Mass | 311.101135 |
| PSA | 143.91000 |
| LogP | 0.60980 |