7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline,phosphoric acid

Modify Date: 2024-01-02 17:01:21

7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline,phosphoric acid structure	Common Name	7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline,phosphoric acid
	CAS Number	911061-10-4	Molecular Weight	927.49100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₄₄Cl₂N₆O₁₆P₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline,phosphoric acid

Piperaquine tetraphosphate is a potent antimalaria agent. Piperaquine tetraphosphate shows inhibition for chloroquine-sensitive and the chloroquine-resistant isolates. Piperaquine tetraphosphate in combination with dihydroartemisinin has the potential for the research of chloroquine-resistant malaria[1][2].

Name	7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline,phosphoric acid
Synonym	More Synonyms

Description	Piperaquine tetraphosphate is a potent antimalaria agent. Piperaquine tetraphosphate shows inhibition for chloroquine-sensitive and the chloroquine-resistant isolates. Piperaquine tetraphosphate in combination with dihydroartemisinin has the potential for the research of chloroquine-resistant malaria[1][2].
Related Catalog	Research Areas >> Infection
In Vitro	Piperaquine tetraphosphate shows high active against all Cameroonian isolates with IC50 of 38.9 nM, range, 7.76-78.3 nM, and shows inhibits against the chloroquine-sensitive and the chloroquine-resistant isolates[1].
References	[1]. asco LK, et al. In vitro activities of piperaquine and other 4-aminoquinolines against clinical isolates of Plasmodium falciparum in Cameroon. Antimicrob Agents Chemother. 2003 Apr;47(4):1391-4. [2]. Salman S,et al. Pharmacokinetic comparison of two piperaquine-containing artemisinin combination therapies in Papua New Guinean children with uncomplicated malaria. Antimicrob Agents Chemother. 2012 Jun;56(6):3288-97.

Molecular Formula	C₂₉H₄₄Cl₂N₆O₁₆P₄
Molecular Weight	927.49100
Exact Mass	926.11400
PSA	389.02000
LogP	1.71550

UNII-IHB5WLO51Q

Piperaquine tetraphosphate

Dichloromethane
CAS#:75-09-2

Polyacrylic acid
CAS#:9003-01-4

sodium carbonate
CAS#:497-19-8

Silicon dioxide
CAS#:7631-86-9

Triethanolamine
CAS#:102-71-6

Demeton
CAS#:126-75-0

Water
CAS#:7732-18-5

4-(4-Piperidinyl)morpholine dihydrochloride
CAS#:53617-35-9

Diclofenac sodium
CAS#:15307-79-6

Budesonide
CAS#:51372-29-3

7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline,phosphoric acid

Use of 7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline,phosphoric acid

Names

Biological Activity

Chemical & Physical Properties

Synonyms