Piperaquine tetraphosphate

Modify Date: 2025-09-26 06:32:00

Piperaquine tetraphosphate Structure
Piperaquine tetraphosphate structure
Common Name Piperaquine tetraphosphate
CAS Number 911061-10-4 Molecular Weight 927.49100
Density N/A Boiling Point N/A
Molecular Formula C29H44Cl2N6O16P4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Piperaquine tetraphosphate


Piperaquine tetraphosphate is a potent antimalaria agent. Piperaquine tetraphosphate shows inhibition for chloroquine-sensitive and the chloroquine-resistant isolates. Piperaquine tetraphosphate in combination with dihydroartemisinin has the potential for the research of chloroquine-resistant malaria[1][2].

 Names

Name 7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline,phosphoric acid
Synonym More Synonyms

 Piperaquine tetraphosphate Biological Activity

Description Piperaquine tetraphosphate is a potent antimalaria agent. Piperaquine tetraphosphate shows inhibition for chloroquine-sensitive and the chloroquine-resistant isolates. Piperaquine tetraphosphate in combination with dihydroartemisinin has the potential for the research of chloroquine-resistant malaria[1][2].
Related Catalog
In Vitro Piperaquine tetraphosphate shows high active against all Cameroonian isolates with IC50 of 38.9 nM, range, 7.76-78.3 nM, and shows inhibits against the chloroquine-sensitive and the chloroquine-resistant isolates[1].
References

[1]. asco LK, et al. In vitro activities of piperaquine and other 4-aminoquinolines against clinical isolates of Plasmodium falciparum in Cameroon. Antimicrob Agents Chemother. 2003 Apr;47(4):1391-4.

[2]. Salman S,et al. Pharmacokinetic comparison of two piperaquine-containing artemisinin combination therapies in Papua New Guinean children with uncomplicated malaria. Antimicrob Agents Chemother. 2012 Jun;56(6):3288-97.

 Chemical & Physical Properties

Molecular Formula C29H44Cl2N6O16P4
Molecular Weight 927.49100
Exact Mass 926.11400
PSA 389.02000
LogP 1.71550

 Synonyms

UNII-IHB5WLO51Q
Piperaquine tetraphosphate
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