Benzthiazide
Modify Date: 2024-01-02 19:35:06
Benzthiazide structure
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Common Name | Benzthiazide | ||
|---|---|---|---|---|
| CAS Number | 91-33-8 | Molecular Weight | 431.93700 | |
| Density | 1.4176 (rough estimate) | Boiling Point | 680.6 °C at 760 mmHg | |
| Molecular Formula | C15H14ClN3O4S3 | Melting Point | 231-232° (U.S. patent); mp 238-239° (P'an) | |
| MSDS | Chinese USA | Flash Point | 365.4 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
Use of BenzthiazideBenzthiazide is a long-acting diuretic[1] and a hypertension agent. Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with Kis of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. Benzthiazide also suppresses proliferation of cancer cells[2]. |
| Name | benzthiazide |
|---|---|
| Synonym | More Synonyms |
| Description | Benzthiazide is a long-acting diuretic[1] and a hypertension agent. Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with Kis of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. Benzthiazide also suppresses proliferation of cancer cells[2]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 8.0 nM (CA9), 8.8 nM (CA2), 10 nM (CA1)[2] |
| In Vitro | Benzthiazide (0.4, 2, 10 μM) suppresses proliferation of cancer cell under hypoxic conditions in a dose-dependent manner . Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with Kis of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively[2]. |
| In Vivo | Benzthiazide (1, 1.5 mg/100 g BW) causes a marked decrease in urinary calcium excretion and the dissociation of calcium and sodium excretion in hyperprolactinemic rats[1]. |
| References |
| Density | 1.4176 (rough estimate) |
|---|---|
| Boiling Point | 680.6 °C at 760 mmHg |
| Melting Point | 231-232° (U.S. patent); mp 238-239° (P'an) |
| Molecular Formula | C15H14ClN3O4S3 |
| Molecular Weight | 431.93700 |
| Flash Point | 365.4 °C |
| Exact Mass | 430.98300 |
| PSA | 160.75000 |
| LogP | 4.86900 |
| Index of Refraction | 1.6100 (estimate) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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Interactions of diuretics with a neutral temperature-responsive polymer: study by capillary electroporesis and dynamic light scattering.
J. Capill. Electrophor. Microchip Technol. 6(5-6) , 163-8, (1999) Interactions between diuretics and a recently synthesized temperature-responsive neutral copolymer, poly(N-isopropyl acrylamide) (PNIPA) grafted with poly(ethyleneoxide) (PEO) (PNIPA-g-PEO) were inves... |
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Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug.
BMC Syst. Biol. 6 , 80, (2012) The process of drug discovery and development is time-consuming and costly, and the probability of success is low. Therefore, there is rising interest in repositioning existing drugs for new medical i... |
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Rapid screening for diuretic doping agents in urine by C60-assisted laser-desorption-ionization-time-of-flight mass spectrometry.
J. Anal. Toxicol. 23(5) , 337-42, (1999) This study describes a matrix-assisted laser-desorption-ionization (MALDI) mass spectrometry for rapid screening of 12 diuretics in spiked urine. C60 is used as the matrix for MALDI. Diuretics are dir... |
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