AZ876
Modify Date: 2025-08-26 20:21:17
AZ876 structure
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Common Name | AZ876 | ||
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| CAS Number | 898800-26-5 | Molecular Weight | 439.570 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 605.3±65.0 °C at 760 mmHg | |
| Molecular Formula | C24H29N3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 319.9±34.3 °C | |
Use of AZ876AZ876 is a novel high-affinity LXR agonist. AZ876 was 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRα and hLXRβ respectively.(1) AZ876 suppressed up-regulation of hypertrophy- and fibrosis-related genes, and further inhibited prohypertrophic and profibrotic transforming growth factor β (TGFβ)-Smad2/3 signalling.(2) AZ876 prevented TGFβ- and angiotensin II-induced fibroblast collagen synthesis, and inhibited up-regulation of the myofibroblastic marker, α-smooth muscle actin.(3) The reference for administration is 20 umol/kg/day in vivo. |
| Name | AZ876 |
|---|---|
| Synonym | More Synonyms |
| Description | AZ876 is a novel high-affinity LXR agonist. AZ876 was 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRα and hLXRβ respectively.(1) AZ876 suppressed up-regulation of hypertrophy- and fibrosis-related genes, and further inhibited prohypertrophic and profibrotic transforming growth factor β (TGFβ)-Smad2/3 signalling.(2) AZ876 prevented TGFβ- and angiotensin II-induced fibroblast collagen synthesis, and inhibited up-regulation of the myofibroblastic marker, α-smooth muscle actin.(3) The reference for administration is 20 umol/kg/day in vivo. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 605.3±65.0 °C at 760 mmHg |
| Molecular Formula | C24H29N3O3S |
| Molecular Weight | 439.570 |
| Flash Point | 319.9±34.3 °C |
| Exact Mass | 439.192963 |
| LogP | 3.27 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.642 |
| InChIKey | IVANYIPLGFVBGR-UHFFFAOYSA-N |
| SMILES | CC(C)(C)N1C(=O)C(Nc2ccc(N3CCCCC3)cc2)=C(c2ccccc2)S1(=O)=O |
| Storage condition | 2-8℃ |
| MFCD30377191 |
| AZ12260493 |
| 2-(2-Methyl-2-propanyl)-5-phenyl-4-{[4-(1-piperidinyl)phenyl]amino}-1,2-thiazol-3(2H)-one 1,1-dioxide |
| 3(2H)-Isothiazolone, 2-(1,1-dimethylethyl)-5-phenyl-4-[[4-(1-piperidinyl)phenyl]amino]-, 1,1-dioxide |