JNJ-38431055 structure
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Common Name | JNJ-38431055 | ||
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CAS Number | 897732-93-3 | Molecular Weight | 479.550 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | 648.3±55.0 °C at 760 mmHg | |
Molecular Formula | C21H29N5O6S | Melting Point | N/A | |
MSDS | N/A | Flash Point | 345.9±31.5 °C |
Use of JNJ-38431055APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119.IC50 value: 46 nM (EC50) [1]Target: hGPR119The design and synthesis of a second generation GPR119-agonist clinical candidate for the treatment of diabetes is described. APD597 was selected for preclinical development based on a good balance between agonist potency, intrinsic activity and in particular on its good solubility and reduced drug-drug interaction potential. [1] |
Name | propan-2-yl 4-[5-methoxy-6-[(2-methyl-6-methylsulfonylpyridin-3-yl)amino]pyrimidin-4-yl]oxypiperidine-1-carboxylate |
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Synonym | More Synonyms |
Description | APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119.IC50 value: 46 nM (EC50) [1]Target: hGPR119The design and synthesis of a second generation GPR119-agonist clinical candidate for the treatment of diabetes is described. APD597 was selected for preclinical development based on a good balance between agonist potency, intrinsic activity and in particular on its good solubility and reduced drug-drug interaction potential. [1] |
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Related Catalog | |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 648.3±55.0 °C at 760 mmHg |
Molecular Formula | C21H29N5O6S |
Molecular Weight | 479.550 |
Flash Point | 345.9±31.5 °C |
Exact Mass | 479.183868 |
PSA | 141.22000 |
LogP | 2.90 |
Vapour Pressure | 0.0±1.9 mmHg at 25°C |
Index of Refraction | 1.570 |
Storage condition | -20℃ |
adp-597 |
Isopropyl 4-[(5-methoxy-6-{[2-methyl-6-(methylsulfonyl)-3-pyridinyl]amino}-4-pyrimidinyl)oxy]-1-piperidinecarboxylate |
1-Piperidinecarboxylic acid, 4-[[5-methoxy-6-[[2-methyl-6-(methylsulfonyl)-3-pyridinyl]amino]-4-pyrimidinyl]oxy]-, 1-methylethyl ester |
JNJ-38431055 |
APD597 |