β-D-glucuronide-pNP-carbonate

Modify Date: 2025-08-26 14:15:13

β-D-glucuronide-pNP-carbonate Structure
β-D-glucuronide-pNP-carbonate structure
Common Name β-D-glucuronide-pNP-carbonate
CAS Number 894095-98-8 Molecular Weight 913.83
Density N/A Boiling Point N/A
Molecular Formula C45H43N3O18 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of β-D-glucuronide-pNP-carbonate


β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

 Names

Name β-D-glucuronide-pNP-carbonate

 β-D-glucuronide-pNP-carbonate Biological Activity

Description β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog
Target

Cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

 Chemical & Physical Properties

Molecular Formula C45H43N3O18
Molecular Weight 913.83
InChIKey DMGQNZOORDYDEZ-LELKPENRSA-N
SMILES COC(=O)C1OC(Oc2ccc(COC(=O)Oc3ccc([N+](=O)[O-])cc3)cc2NC(=O)CCNC(=O)OCC2c3ccccc3-c3ccccc32)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O
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