Imidaprilate

Modify Date: 2025-08-21 08:52:28

Imidaprilate structure	Common Name	Imidaprilate
	CAS Number	89371-44-8	Molecular Weight	377.39200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₃N₃O₆	Melting Point	180-182ºC
	MSDS	N/A	Flash Point	N/A

Use of Imidaprilate

Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease.

Name	(4S)-3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid
Synonym	More Synonyms

Description	Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cardiovascular Disease
Target	IC50: 2.6 nM (ACE)[1]
In Vitro	Imidaprilate (6366A) is an active metabolite of 6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM. Imidaprilate augments the bradykinin-induced contraction of guinea pig ileum, with AC50 of 1.7 nM[1].
In Vivo	Imidaprilate (≥0.2 mg/kg) inhibits angiotensin I (AT-I)-induced pressor response. TA-6366 lowers the blood pressure in two-kidney one-clip renal hypertensive rats at 0.5-2 mg/kg via oral administration, and in spontaneously hypertensive rats (SHRs) at 2 to 10 mg/kg[1].
References	[1]. Kubo M, et al. Pharmacological studies on (4S)-1-methyl-3-[(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino] propionyl]-2-oxo-imidazolidine-4-carboxylic acid hydrochloride (TA-6366), a new ACE inhibitor: I. ACE inhibitory and anti-hypertensive activities. Jpn J Pharmacol. 1990 Jun;53(2):201-10.

Melting Point	180-182ºC
Molecular Formula	C₁₈H₂₃N₃O₆
Molecular Weight	377.39200
Exact Mass	377.15900
PSA	127.25000
LogP	0.66440
InChIKey	VFAVNRVDTAPBNR-UBHSHLNASA-N
SMILES	CC(NC(CCc1ccccc1)C(=O)O)C(=O)N1C(=O)N(C)CC1C(=O)O

Precursor 8
CAS#:89460-20-8 Imidaprilat Ben... CAS#:16503-46-1 2-Bromo-4-pheny... CAS#:1012-05-1 DL-Homophenylalanine CAS#:5440-40-4 Benzenebutanoic...
CAS#:943-73-7 L-Homophenylalanine CAS#:89371-42-6 N-[1-(S)-Benzyl... CAS#:117560-14-2 N-[1-(S)-Benzyl... CAS#:83056-79-5 tert-butyl(4s)-...
DownStream 0

(4S)-3-<(2S)-2-<N-((1S)-1-carboxy-3-phenylpropyl)amino>propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylic acid

(4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-carboxy-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid

UNII-WUU07Y30IA

Imidapril Diacid

Imidaprilat

(4S)-3-[(2S)-N-[(1S)-1-carboxy-3-phenylpropyl]alanyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Imidaprilat
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: IMIDAPRILAT
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang
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