UK51656

Modify Date: 2024-01-17 09:51:03

UK51656 Structure
UK51656 structure
Common Name UK51656
CAS Number 88150-59-8 Molecular Weight 465.92700
Density N/A Boiling Point N/A
Molecular Formula C22H28ClN3O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of UK51656


UK51656 is a calcium antagonist with IC50 of 4 nM.

 Names

Name uk-51656
Synonym More Synonyms

 UK51656 Biological Activity

Description UK51656 is a calcium antagonist with IC50 of 4 nM.
Related Catalog
Target

IC50: 4 nM (calcium)[1]

In Vivo UK51656 has an elimination half-life of 4.7 h, which is consistent with its duration of action in the anesthetized dog. The effect of UK51656 on coronary vascular resistance, has markedly long durations, being over 5 h[1].
References

[1]. Alker D, et al. Long-acting dihydropyridine calcium antagonists. 4. Synthesis and structure-activity relationships for a series of basic and nonbasic derivatives of 2-[(2-aminoethoxy)methyl]-1,4-dihydropyridine calcium antagonists. J Med Chem. 1990 Feb;33(2):585-91.

 Chemical & Physical Properties

Molecular Formula C22H28ClN3O6
Molecular Weight 465.92700
Exact Mass 465.16700
PSA 128.98000
LogP 2.80250
Storage condition 2-8℃

 Synonyms

2-(2-{[4-(2-Chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}ethylamino)acetamide
2-[2-(Carbamoylmethyl-amino)-ethoxymethyl]-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
2-<<2-<N-<(aminocarbonyl)methyl>amino>ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine
UK51656
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