KPT-6566

Modify Date: 2024-01-08 02:21:14

KPT-6566 structure	Common Name	KPT-6566
	CAS Number	881487-77-0	Molecular Weight	443.54
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₁NO₅S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of KPT-6566

KPT-6566, a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 of 640 nM and a Ki of 625.2 nM for PIN1 PPIase domain. Anti-cancer activity[1].

Name	KPT-6566

Description	KPT-6566, a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 of 640 nM and a Ki of 625.2 nM for PIN1 PPIase domain. Anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 640 nM (PIN1 PPIase)[1] Ki: 625.2 nM (PIN1 PPIase)[1]
References	[1]. Campaner E, et al. A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action. Nat Commun. 2017 Jun 9;8:15772.

Molecular Formula	C₂₂H₂₁NO₅S₂
Molecular Weight	443.54

DC Chemicals Limited
China
Product Name: KPT-6566
Price: $950.0/100mg $1700.0/250mg $3800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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