UoS 12258
Modify Date: 2024-04-11 09:33:16
UoS 12258 structure
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Common Name | UoS 12258 | ||
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| CAS Number | 875927-64-3 | Molecular Weight | 334.408 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 502.5±60.0 °C at 760 mmHg | |
| Molecular Formula | C17H19FN2O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 257.7±32.9 °C | |
Use of UoS 12258UoS12258 (UoS-12258) is a selective, positive allosteric modulator of the AMPA receptor with pEC50 of 5.6; displays excellent wide selectivity against a wide range of other ion channels (including hERG, NMDA, and kainate channels), enzymes, and GPCRs; displays a minimum effective concentration of approximately 10 nM in vitro and enhances AMPA receptor-mediated synaptic transmission at an estimated free brain concentration of approximately 15 nM in vivo; exhibits cognition enhancing properties in several rat behavioural models. |
| Name | N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide |
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| Synonym | More Synonyms |
| Description | UoS12258 (UoS-12258) is a selective, positive allosteric modulator of the AMPA receptor with pEC50 of 5.6; displays excellent wide selectivity against a wide range of other ion channels (including hERG, NMDA, and kainate channels), enzymes, and GPCRs; displays a minimum effective concentration of approximately 10 nM in vitro and enhances AMPA receptor-mediated synaptic transmission at an estimated free brain concentration of approximately 15 nM in vivo; exhibits cognition enhancing properties in several rat behavioural models. |
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| References | References 1. Ward SE, et al. J Med Chem. 2010 Aug 12;53(15):5801-12. 2. Ward SE, et al. Br J Pharmacol. 2017 Mar;174(5):370-385. View Related Products by Target iGluR |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 502.5±60.0 °C at 760 mmHg |
| Molecular Formula | C17H19FN2O2S |
| Molecular Weight | 334.408 |
| Flash Point | 257.7±32.9 °C |
| Exact Mass | 334.115112 |
| LogP | 2.68 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.604 |
| 2-Propanesulfonamide, N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]- |
| N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide |