YIL-781
Modify Date: 2025-08-25 14:42:35
YIL-781 structure
|
Common Name | YIL-781 | ||
|---|---|---|---|---|
| CAS Number | 875258-85-8 | Molecular Weight | 409.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H28FN3O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of YIL-781YIL781 is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 produces a greater improvement in glucose homeostasis in rats. YIL781 inhibits the calcium response induced by ghrelin with pIC50 values of 7.90 and 8.27, respectively[1][2][3][4]. |
| Name | 6-(4-Fluorophenoxy)-3-{[(3S)-1-isopropyl-3-piperidinyl]methyl}-2- methyl-4(3H)-quinazolinone hydrochloride (1:1) |
|---|---|
| Synonym | More Synonyms |
| Description | YIL781 is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 produces a greater improvement in glucose homeostasis in rats. YIL781 inhibits the calcium response induced by ghrelin with pIC50 values of 7.90 and 8.27, respectively[1][2][3][4]. |
|---|---|
| Related Catalog | |
| In Vitro | YIL781 (10-300 nM) 诱导生长素释放肽 CRC 的浓度依赖性平行右移，在 100 和 300 nM 时最大反应有轻微但具有统计学意义的抑制，达到约 90% 的类似激动剂最大反应[3]。 |
| In Vivo | YIL781 (0.1-5 μg/5 μL) 减弱生长素释放肽诱导的血糖水平上调。而单独使用 YIL781 不会影响血糖水平[4]。 |
| References |
| Molecular Formula | C24H28FN3O2 |
|---|---|
| Molecular Weight | 409.50 |
| Exact Mass | 445.19300 |
| PSA | 47.36000 |
| LogP | 5.49660 |
| InChIKey | QQGRMONBDBMLSP-FERBBOLQSA-N |
| SMILES | Cc1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1CC1CCCN(C(C)C)C1.Cl |
| Mesulergine hydrochloride |
| YIL-781 |