(2S,3S)-N-benzyl-1,1-dimethoxy-N,3-dimethylpentan-2-amine

Modify Date: 2022-01-14 21:28:07

(2S,3S)-N-benzyl-1,1-dimethoxy-N,3-dimethylpentan-2-amine Structure
(2S,3S)-N-benzyl-1,1-dimethoxy-N,3-dimethylpentan-2-amine structure
Common Name (2S,3S)-N-benzyl-1,1-dimethoxy-N,3-dimethylpentan-2-amine
CAS Number 870640-61-2 Molecular Weight 265.391
Density 1.0±0.1 g/cm3 Boiling Point 329.1±27.0 °C at 760 mmHg
Molecular Formula C16H27NO2 Melting Point N/A
MSDS N/A Flash Point 106.1±10.7 °C

 Use of (2S,3S)-N-benzyl-1,1-dimethoxy-N,3-dimethylpentan-2-amine


Monomethyl auristatin E intermediate-12 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

 Names

Name (2S,3S)-N-Benzyl-1,1-dimethoxy-N,3-dimethyl-2-pentanamine
Synonym More Synonyms

  Biological Activity

Description Monomethyl auristatin E intermediate-12 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
Related Catalog
References

[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.  

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 329.1±27.0 °C at 760 mmHg
Molecular Formula C16H27NO2
Molecular Weight 265.391
Flash Point 106.1±10.7 °C
Exact Mass 265.204193
LogP 2.59
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.492

 Synonyms

Benzenemethanamine, N-[(1S,2S)-1-(dimethoxymethyl)-2-methylbutyl]-N-methyl-
MFCD28385889
(2S,3S)-N-Benzyl-1,1-dimethoxy-N,3-dimethyl-2-pentanamine
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