AH-3960

Modify Date: 2024-01-31 11:58:55

AH-3960 structure	Common Name	AH-3960
	CAS Number	862907-48-0	Molecular Weight	282.33900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₂₂N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AH-3960

AH3960 (compound 16c) is an antagonist of androgen receptor. AH3960 binds wild as well as T877 mutant type androgen receptors. AH3960 selectively inhibits T877 with an IC50 value of 0.82 μM. AH3960 also serves as an agonist of parathyroid hormone receptor-1 (PTHR1)[1][2].

Name	1,3-Dibutyl-5-(diaminomethylene)-2,4,6(1H,3H,5H)-pyrimidinetrione
Synonym	More Synonyms

Description	AH3960 (compound 16c) is an antagonist of androgen receptor. AH3960 binds wild as well as T877 mutant type androgen receptors. AH3960 selectively inhibits T877 with an IC50 value of 0.82 μM. AH3960 also serves as an agonist of parathyroid hormone receptor-1 (PTHR1)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Thyroid Hormone Receptor Signaling Pathways >> Others >> Androgen Receptor
References	[1]. Yamamoto S, et al. Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists. Bioorg Med Chem. 2012 Apr 1;20(7):2338-52. [2]. Carter PH, et al. Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor. Mol Endocrinol. 2015 Feb;29(2):307-21.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Thyroid Hormone Receptor

Signaling Pathways >> Others >> Androgen Receptor

References

[1]. Yamamoto S, et al. Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists. Bioorg Med Chem. 2012 Apr 1;20(7):2338-52.

[2]. Carter PH, et al. Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor. Mol Endocrinol. 2015 Feb;29(2):307-21.