Tyroserleutide hydrochloride
Modify Date: 2025-08-24 20:31:30
Tyroserleutide hydrochloride structure
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Common Name | Tyroserleutide hydrochloride | ||
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| CAS Number | 852982-42-4 | Molecular Weight | 417.88 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H28ClN3O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Tyroserleutide hydrochlorideTyroserleutide hydrochloride, isolated from the degradation products of porcine spleen[1], is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo[2]. |
| Name | Tyroserleutide hydrochloride |
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| Description | Tyroserleutide hydrochloride, isolated from the degradation products of porcine spleen[1], is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo[2]. |
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| Related Catalog | |
| Target |
Antitumor tripeptide[1][2] |
| In Vitro | Tyroserleutide (YSL) exhibits immuno-modulating effects, such as enhancing concanavalin (ConA) induced proliferation of mouse spleen lymphocytes, phagocytosis of mouse peritoneal macrophages, and the activity of natural killer (NK) cells[1]. Tyroserleutide (YSL), an immunologically therapeutic tripeptide, can promote hepatocarcinoma cell (H22) apoptosis through downregulating Bcl-2 and cyclin D1 expression[2]. Tyroserleutide is an ideal choice for inducing apoptosis of liver tumor cells[2]. Tyroserleutide inhibits tumor growth and does not cause severe toxicities in the major organs. Tyroserleutide can inhibit tumor cell migration[2]. |
| In Vivo | Tyroserleutide (10-80 μg/kg; injection (i.p.) one time every day until mice are dead) displays obvious anti-tumor activity. Tyroserleutide significantly prolongs the survival time of the murine H22 implanted mice[1]. Animal Model: Female Kun-Ming mice (18-22 g, 6 week old) with H22 tumor model[1] Dosage: 10, 20, 40, and 80 μg/kg Administration: Injection (i.p.) one time every day until mice were dead. Result: Survival times are 25.53±14.14, 25.82±14.29, 30.47±17.89, 35.06±20.90 days for 10, 20, 40, and 80 μg/kg, respectively. |
| References |
| Molecular Formula | C18H28ClN3O6 |
|---|---|
| Molecular Weight | 417.88 |
| InChIKey | VQJGHKJCNANIKM-WDTSGDEMSA-N |
| SMILES | CC(C)CC(NC(=O)C(CO)NC(=O)C(N)Cc1ccc(O)cc1)C(=O)O.Cl |