JNJ-18038683 free base

Modify Date: 2025-08-25 19:18:46

JNJ-18038683 free base Structure
JNJ-18038683 free base structure
Common Name JNJ-18038683 free base
CAS Number 851373-91-6 Molecular Weight 337.846
Density 1.3±0.1 g/cm3 Boiling Point 547.6±50.0 °C at 760 mmHg
Molecular Formula C20H20ClN3 Melting Point N/A
MSDS N/A Flash Point 285.0±30.1 °C

 Use of JNJ-18038683 free base


JNJ-18038683 is a potent, selective 5-HT7 receptor antagonist with pKi of 8.19 and 8.20 for rat and human 5-HT7 in cell-based assays; decreases 5-HT (100 nM)-stimulated adenylyl cyclase in rat and human 5-HT7/HEK293 cells with pKb of 8.01 and 7.99, respectively; shows 10-fold selectivity over h5-HT6 receptor, 15-fold selectivity over rat adrenergic α1 receptor, 14- to 25-fold selectivity over the h5-HT2 receptor subtypes, and 20-fold selectivity over h5-HT1B receptor; prolongs rapid eye movement (REM) sleep and decreases REM duration induced by citalopram in vivo.

 Names

Name JNJ-18038683 FREE BASE
Synonym More Synonyms

 JNJ-18038683 free base Biological Activity

Description JNJ-18038683 is a potent, selective 5-HT7 receptor antagonist with pKi of 8.19 and 8.20 for rat and human 5-HT7 in cell-based assays; decreases 5-HT (100 nM)-stimulated adenylyl cyclase in rat and human 5-HT7/HEK293 cells with pKb of 8.01 and 7.99, respectively; shows 10-fold selectivity over h5-HT6 receptor, 15-fold selectivity over rat adrenergic α1 receptor, 14- to 25-fold selectivity over the h5-HT2 receptor subtypes, and 20-fold selectivity over h5-HT1B receptor; prolongs rapid eye movement (REM) sleep and decreases REM duration induced by citalopram in vivo.
References References 1. Bonaventure P, et al. J Pharmacol Exp Ther. 2012 Aug;342(2):429-40. 2. Shelton J, et al. Front Behav Neurosci. 2015 Jan 15;8:453. View Related Products by Target Histamine Receptor

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 547.6±50.0 °C at 760 mmHg
Molecular Formula C20H20ClN3
Molecular Weight 337.846
Flash Point 285.0±30.1 °C
Exact Mass 337.134583
LogP 3.84
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.656

 Synonyms

Pyrazolo[3,4-d]azepine, 3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydro-1-(phenylmethyl)-
1-Benzyl-3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine
JNJ-18038683 FREE BASE
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here



Get all suppliers and price by the below link:

JNJ-18038683 free base suppliers

JNJ-18038683 free base price