MAO-B-IN-5
Modify Date: 2025-09-21 17:05:03
MAO-B-IN-5 structure
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Common Name | MAO-B-IN-5 | ||
|---|---|---|---|---|
| CAS Number | 849909-77-9 | Molecular Weight | 328.38 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H21FN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MAO-B-IN-5MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 µM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD)[1]. |
| Name | MAO-B-IN-5 |
|---|
| Description | MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 µM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD)[1]. |
|---|---|
| Related Catalog | |
| Target |
MAO-B:34.190 μM (IC50) MAO-A:0.204 μM (IC50) |
| In Vitro | MAO-B-IN-5 (compound D0) (Sf9 cells) shows inhibitory activities towards MAO with the IC50s of 34.190 µM and 0.204 µM for MAO-A and MAO-B, respectively[1]. |
| In Vivo | MAO-B-IN-5 (1 mg/kg, i.v.; 5 mg/kg, p.o.) shows oral bioavailability in rats (F=13.6%)[1]. Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats[1]. Compound Route Dose (mg/kg) Cmax (ng/mL) AUCt (ng·h/mL) T1/2 (h) Vss (h) Cl (mL/min/kg) F (%) D0 iv 1 809 347 0.37 1.11 47.1 / po 5 163 284 1.27 / / 16.3SD rats; 1 mg/kg, i.v.; 5 mg/kg, p.o.[1]. Animal Model: SD rats[1] Dosage: 1, 5 mg/kg Administration: 1 mg/kg, i.v.; 5 mg/kg, p.o. Result: Showed oral bioavailability in rats (F=16.3%). |
| References |
| Molecular Formula | C19H21FN2O2 |
|---|---|
| Molecular Weight | 328.38 |