Helioxanthin 8-1

Modify Date: 2024-01-21 12:05:34

Helioxanthin 8-1 structure	Common Name	Helioxanthin 8-1
	CAS Number	840529-13-7	Molecular Weight	376.319
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₂N₂O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Helioxanthin 8-1

Helioxanthin 8-1 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 uM.IC50 value: >5/10/1.4/15 uM(HBV/HCV/HSV-1/HIV) [1]Target: Antiviral agentThe cyclic hydrazide 28(Helioxanthin 8-1) showed the most potent antiHBV activity among those helioxanthin analogues tested. In addition, compound 28 exhibited moderately potent activity against HIV. It would therefore be promising to study helioxanthin analogues that contain a six-membered ring instead of the five-membered ring found in the lactam [1]. 8-1 exhibited effective inhibition on DHBV replication. The combination of 8-1 with 3TC resulted in additional anti-DHBV activity. Viral induced cells displayed higher susceptibility to 8-1 treatment than non-induced cells. HBV X protein might not be an essential factor in the initiation of the biological activity of 8-1, as demonstrated by its absence in DHBV [2].

Name	1,3-Benzodioxolo[4,5-g]phthalazine-7,10-dione, 11-(1,3-benzodioxol-5-yl)-8,9-dihydro
Synonym	More Synonyms

Description	Helioxanthin 8-1 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 uM.IC50 value: >5/10/1.4/15 uM(HBV/HCV/HSV-1/HIV) [1]Target: Antiviral agentThe cyclic hydrazide 28(Helioxanthin 8-1) showed the most potent antiHBV activity among those helioxanthin analogues tested. In addition, compound 28 exhibited moderately potent activity against HIV. It would therefore be promising to study helioxanthin analogues that contain a six-membered ring instead of the five-membered ring found in the lactam [1]. 8-1 exhibited effective inhibition on DHBV replication. The combination of 8-1 with 3TC resulted in additional anti-DHBV activity. Viral induced cells displayed higher susceptibility to 8-1 treatment than non-induced cells. HBV X protein might not be an essential factor in the initiation of the biological activity of 8-1, as demonstrated by its absence in DHBV [2].
Related Catalog	Signaling Pathways >> Anti-infection >> HBV Research Areas >> Infection
References	[1]. Yeo H, et al. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46. [2]. Ying C, et al. Helioxanthin analogue 8-1 inhibits duck hepatitis B virus replication in cell culture. Antivir Chem Chemother. 2010;21(2):97-103.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> HBV

Research Areas >> Infection

References

[1]. Yeo H, et al. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.

[2]. Ying C, et al. Helioxanthin analogue 8-1 inhibits duck hepatitis B virus replication in cell culture. Antivir Chem Chemother. 2010;21(2):97-103.

Density	1.5±0.1 g/cm3
Molecular Formula	C₂₀H₁₂N₂O₆
Molecular Weight	376.319
Exact Mass	376.069550
PSA	102.64000
LogP	3.29
Index of Refraction	1.715
Storage condition	2-8℃

Helioxanthin 8-1

11-(1,3-Benzodioxol-5-yl)-8,9-dihydro[1,3]benzodioxolo[4,5-g]phthalazine-7,10-dione

1,3-Benzodioxolo[4,5-g]phthalazine-7,10-dione, 11-(1,3-benzodioxol-5-yl)-8,9-dihydro-

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Helioxanthin 8-1
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang

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Helioxanthin 8-1

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