Tetrahydrozoline

Modify Date: 2025-08-25 17:20:29

Tetrahydrozoline structure	Common Name	Tetrahydrozoline
	CAS Number	84-22-0	Molecular Weight	200.28000
	Density	1.2 g/cm3	Boiling Point	393.5ºC at 760 mmHg
	Molecular Formula	C₁₃H₁₆N₂	Melting Point	N/A
	MSDS	N/A	Flash Point	191.8ºC

Use of Tetrahydrozoline

Tetrahydrozoline is a potent α-adrenergic agonist and causes vasoconstriction. Tetrahydrozoline is used for the relief of conjunctival, ophthalmic and nasal congestion in vivo[1][2].

Name	tetryzoline
Synonym	More Synonyms

Description	Tetrahydrozoline is a potent α-adrenergic agonist and causes vasoconstriction. Tetrahydrozoline is used for the relief of conjunctival, ophthalmic and nasal congestion in vivo[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
References	[1]. E Kisilevsky, et al. Anterior and posterior segment vasculopathy associated with long-term use of tetrahydrozoline. CMAJ. 2018 Oct 9;190(40):E1208. [2]. Judy Peat, et al.Determination of tetrahydrozoline in urine and blood using gas chromatography-mass spectrometry (GC-MS). Methods Mol Biol

Description

Tetrahydrozoline is a potent α-adrenergic agonist and causes vasoconstriction. Tetrahydrozoline is used for the relief of conjunctival, ophthalmic and nasal congestion in vivo[1][2].

Related Catalog

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

References

[1]. E Kisilevsky, et al. Anterior and posterior segment vasculopathy associated with long-term use of tetrahydrozoline. CMAJ. 2018 Oct 9;190(40):E1208.

[2]. Judy Peat, et al.Determination of tetrahydrozoline in urine and blood using gas chromatography-mass spectrometry (GC-MS). Methods Mol Biol

Density	1.2 g/cm3
Boiling Point	393.5ºC at 760 mmHg
Molecular Formula	C₁₃H₁₆N₂
Molecular Weight	200.28000
Flash Point	191.8ºC
Exact Mass	200.13100
PSA	24.39000
LogP	1.87260
Index of Refraction	1.656
Storage condition	-20℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ4525000

CHEMICAL NAME :: 2-Imidazoline, 2-(1,2,3,4-tetrahydro-1-naphthyl)-

CAS REGISTRY NUMBER :: 84-22-0

BEILSTEIN REFERENCE NO. :: 0011442

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C13-H16-N2

MOLECULAR WEIGHT :: 200.31

WISWESSER LINE NOTATION :: L66&TJ G- BT5M CN BUTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 186 nL/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 2,217,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 150 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - hallucinations, distorted perceptions Behavioral - irritability

REFERENCE :: AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038) Volume(issue)/page/year: 20,655,1991

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,580,1969

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 375 nL/kg

TOXIC EFFECTS :: Behavioral - wakefulness Behavioral - somnolence (general depressed activity)

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 2,217,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 335 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,971,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 116 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,971,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 252 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,971,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 48100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,699,1990

1,2-Ethanediamine

CAS#:107-15-3

Tetrahydrozoline

CAS#:84-22-0

Literature: DE1009189 , ; US2731471 , ;

N/A

CAS#:132205-64-2

Ethane-1,2-diam...

CAS#:14034-59-4

Tetrahydrozoline

CAS#:84-22-0

Literature: DE1009189 , ; US2731471 , ;

Precursor 2
CAS#:107-15-3 1,2-Ethanediamine CAS#:14034-59-4 Ethane-1,2-diam...
DownStream 0

2-tetralin-1-yl-4,5-dihydro-1H-imidazole

EINECS 201-522-3

Tetrahydrozolinum

tetrahydrozoline

Tyzanol

2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole

Tetryzoline

Tetryzolin

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tetrahydrozoline
Price: Check
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Tetrahydrozoline
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: tetryzoline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Shanghai Amole Biotechnology Co., Ltd.
China
Product Name: Tetrahydrozoline
Price: ￥Inquiry/100mg ￥Inquiry/1g ￥Inquiry/250mg
Purity: 98.0%
Delivery: Inquiry
Contact: Xiyao Wang
Email: 406104890@qq.com

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