Delapril

Modify Date: 2024-02-01 00:57:43

Delapril structure	Common Name	Delapril
	CAS Number	83435-66-9	Molecular Weight	452.54
	Density	1.22g/cm3	Boiling Point	659.7ºC at 760 mmHg
	Molecular Formula	C₂₆H₃₂N₂O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	352.7ºC

Use of Delapril

Delapril (CV-3317) is an orally active angiotensin I converting enzyme (ACE) inhibitor. Delapril has antihypertensive activity[1].

Name	2-[2,3-dihydro-1H-inden-2-yl-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]acetic acid
Synonym	More Synonyms

Description	Delapril (CV-3317) is an orally active angiotensin I converting enzyme (ACE) inhibitor. Delapril has antihypertensive activity[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
In Vivo	Delapril (5-20 mg/kg，饮用水喂养) 可减缓胆固醇喂养兔的动脉粥样硬化进展[2]。 Delapril (1-10 mg/kg，p.o.，每日一次，持续 5 周) 在高血压大鼠中表现出自发的抗高血压作用[3]。 Animal Model: Cholesterol-fed rabbits[2] Dosage: 5 mg/kg at D5, 10 mg/kg at D10, 20 mg/kg at D20 Administration: Fed in a fixed volume (10 ml) of drinking water Result: Decreased aortic area covered by lesions. Restored endothelium-dependent relaxation
References	[1]. Onoyama K, et al. Pharmacokinetics of a new angiotensin I converting enzyme inhibitor (delapril) in patients with deteriorated kidney function and in normal control subjects. Clin Pharmacol Ther. 1988 Mar;43(3):242-9. [2]. Hernandez A,et al. Delapril slows the progression of atherosclerosis and maintains endothelial function in cholesterol-fed rabbits. Atherosclerosis. 1998 Mar;137(1):71-6. [3]. Inada Y, et al. Antihypertensive action of a non-sulfhydryl angiotensin converting enzyme inhibitor (CV-3317) in various hypertensive models. Jpn J Pharmacol. 1986 Sep;42(1):1-8.

Density	1.22g/cm3
Boiling Point	659.7ºC at 760 mmHg
Molecular Formula	C₂₆H₃₂N₂O₅
Molecular Weight	452.54
Flash Point	352.7ºC
Exact Mass	452.23100
PSA	95.94000
LogP	3.00050
Index of Refraction	1.595

Delaket (TN)

Alindapril

Glycine,N-(2,3-dihydro-1H-inden-2-yl)-N-(N-(1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-,(S)

Glycine,N-((1S)-1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)

DELAPRIL

Delaprilum [Latin]

Delapril [INN]

Delaprilum

DC Chemicals Limited
China
Product Name: Delapril
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Benazepril
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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