833481-77-9

Modify Date: 2025-09-23 12:18:34

833481-77-9 structure	Common Name	N/A
	CAS Number	833481-77-9	Molecular Weight	282.34
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₈N₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 833481-77-9

Hydroxy-PP-Me is a potent and specific CBR1 inhibitor with an IC50 of 759 nM. Hydroxy-PP-Me inhibits serum-withdrawal-induced apoptosis. Hydroxy-PP-Me increases As2O3-induced apoptotic cell death compared with As2O3 alone[1][2].

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Description	Hydroxy-PP-Me is a potent and specific CBR1 inhibitor with an IC50 of 759 nM. Hydroxy-PP-Me inhibits serum-withdrawal-induced apoptosis. Hydroxy-PP-Me increases As2O3-induced apoptotic cell death compared with As2O3 alone[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	IC50: 759 nM (CBR1)[1]
References	[1]. Tanaka M, et al. An unbiased cell morphology-based screen for new, biologically active small molecules. PLoS Biol. 2005 May;3(5):e128. [2]. Jang M, et al. Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. Cancer Res. 2012 Aug 15;72(16):4214-24.

Molecular Formula	C₁₆H₁₈N₄O
Molecular Weight	282.34
Exact Mass	282.14800
PSA	62.97000
LogP	3.49950
InChIKey	CHOWNNXMRTVILJ-UHFFFAOYSA-N
SMILES	CNc1ncnc2c1c(-c1cccc(O)c1)cn2C(C)C

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 化合物 Hydroxy-PP-Me
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

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833481-77-9 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.