GSK983
Modify Date: 2024-11-27 21:08:03
GSK983 structure
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Common Name | GSK983 | ||
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| CAS Number | 827591-02-6 | Molecular Weight | 325.79200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H16ClN3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GSK983GSK983 is a broad-spectrum antiviral agent. GSK983 inhibits the replication of adenovirus-5 (Ad-5) and polyoma virus SV40. GSK983 inhibits the growth of cell lines immortalized by EBV, HTLV1, HPV. GSK983 induces the expression of interferon-stimulated genes[1]. |
| Name | N-[(1R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]pyridine-2-carboxamide |
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| Synonym | More Synonyms |
| Description | GSK983 is a broad-spectrum antiviral agent. GSK983 inhibits the replication of adenovirus-5 (Ad-5) and polyoma virus SV40. GSK983 inhibits the growth of cell lines immortalized by EBV, HTLV1, HPV. GSK983 induces the expression of interferon-stimulated genes[1]. |
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| Related Catalog | |
| In Vitro | GSK983 (0-10000 nM; 2 h) 抑制原代人成纤维细胞 (HFF) 中腺病毒 5 (Ad-5) 和 Vero 细胞中多瘤病毒 SV40 的复制，中值效应浓度 (K) 分别为 21 nM、7.5 nM； 最大抑制率 (I max) 分别为 99%、88%[1]。 GSK983 (0-10000 nM; 72 h) 抑制通过病毒感染永生化的细胞系的生长，对 IM9 (EBV)，B-LCL 5/2/1 ( EBV), MT4 (HTLV1) 细胞的中值效应浓度 (K) 分别为 16, 14, 7.5 nM[1]. GSK983 (10, 100 nM; 24, 48 h) 在 W12, HKC 细胞中诱导干扰素刺激基因的表达[1]。 RT-PCR[1] Cell Line: W12, HKC cells Concentration: 10, 100 nM Incubation Time: 24, 48 h Result: Induced the expression of interferon-stimulated genes in infected and immortalized cells, increased the gene expression of CSF2, IFIT1 (ISG56), IL6, ISG15, OAS1, OAS2, OASL and TNFSF10 (TRAIL). |
| References |
| Molecular Formula | C18H16ClN3O |
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| Molecular Weight | 325.79200 |
| Exact Mass | 325.09800 |
| PSA | 61.27000 |
| LogP | 4.59850 |
| gsk983 |