FEN1-IN-7

Modify Date: 2025-11-28 16:12:46

FEN1-IN-7 structure	Common Name	FEN1-IN-7
	CAS Number	824983-90-6	Molecular Weight	362.36
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₄N₂O₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FEN1-IN-7

FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents[1].

Name	FEN1-IN-7

Description	FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> FLAP
References	[1]. Tumey LN, et al. The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett. 2005 Jan 17;15(2):277-81.

Molecular Formula	C₁₆H₁₄N₂O₆S
Molecular Weight	362.36
InChIKey	QSJHVKLMLSCTRZ-UHFFFAOYSA-N
SMILES	COc1cc(Cn2c(=O)n(O)c(=O)c3c(C)csc32)cc2c1OCO2

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FEN1-IN-7

Use of FEN1-IN-7

Names

FEN1-IN-7 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.