CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
YY8158000
-
CHEMICAL NAME :
-
Vincaleukoblastine, O(sup 4)-deacetyl-3-de(methoxycarbonyl)-3-(((2-ethoxy-1-(1H -indol-3- ylmethyl)-2-oxoethyl)amino)carbonyl)-, (23(S))-
-
CAS REGISTRY NUMBER :
-
81600-06-8
-
LAST UPDATED :
-
199403
-
DATA ITEMS CITED :
-
1
-
MOLECULAR FORMULA :
-
C56-H68-N6-O9
-
MOLECULAR WEIGHT :
-
969.30
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
94 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
REFERENCE :
-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 28,1079,1985
|
