Sanggenon C

Modify Date: 2025-08-23 11:57:47

Sanggenon C structure	Common Name	Sanggenon C
	CAS Number	80651-76-9	Molecular Weight	708.707
	Density	1.5±0.1 g/cm3	Boiling Point	999.3±65.0 °C at 760 mmHg
	Molecular Formula	C₄₀H₃₆O₁₂	Melting Point	N/A
	MSDS	N/A	Flash Point	312.7±27.8 °C

Use of Sanggenon C

Sanggenon C is a flavanone Diels-Alder adduct compound, which is isolated from the root bark of Morus cathayana. Sanggenon C exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and tumor necrosis factor-α-stimulated cell adhesion and vascular cell adhesion molecule-1 expression, by suppressing NF-κB activity[1]. Sanggenon C possesses antioxidant, anti-inflammatory activities and inhibits Pancreatic lipase (PL) with the an IC50 of 3.00 μM[2].

Name	2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-1,3,8,10a-tetrahydroxy-5a-(3-methylbut-2-enyl)-[1]benzofuro[3,2-b]chromen-11-one
Synonym	More Synonyms

Description	Sanggenon C is a flavanone Diels-Alder adduct compound, which is isolated from the root bark of Morus cathayana. Sanggenon C exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and tumor necrosis factor-α-stimulated cell adhesion and vascular cell adhesion molecule-1 expression, by suppressing NF-κB activity[1]. Sanggenon C possesses antioxidant, anti-inflammatory activities and inhibits Pancreatic lipase (PL) with the an IC50 of 3.00 μM[2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology
Target	NF-κB
References	[1]. Xiao L, et al. Sanggenon C protects against pressure overload induced cardiac hypertrophy via the calcineurin/NFAT2 pathway. Mol Med Rep. 2017 Oct;16(4):5338-5346. [2]. Hou XD , et al. Natural constituents from Cortex Mori Radicis as new pancreatic lipase inhibitors. Bioorg Chem. 2018 Oct;80:577-584.

Density	1.5±0.1 g/cm3
Boiling Point	999.3±65.0 °C at 760 mmHg
Molecular Formula	C₄₀H₃₆O₁₂
Molecular Weight	708.707
Flash Point	312.7±27.8 °C
Exact Mass	708.220703
PSA	214.44000
LogP	7.94
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.727
InChIKey	XETHJOZXBVWLLM-QAHMVTMMSA-N
SMILES	CC(C)=CCC12Oc3cc(O)c(C4C=C(C)CC(c5ccc(O)cc5O)C4C(=O)c4ccc(O)cc4O)c(O)c3C(=O)C1(O)Oc1cc(O)ccc12
Storage condition	2-8℃

2-[(1S,5S,6R)-6-(2,4-Dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)-5a,10a-dihydro-11H-[1]benzofuro[3,2-b]chromen-11-one

sanggenon D

Sanggenon C

2-[(1S,5S,6R)-6-(2,4-Dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-1,3,5a,8-tetrahydroxy-10a-(3-methyl-2-buten-1-yl)-5a,10a-dihydro-11H-[1]benzofuro[3,2-b]chromen-11-one

11H-Benzofuro[3,2-b][1]benzopyran-11-one, 2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,5a,8-tetrahydroxy-10a-(3-methyl-2-buten-1-yl)-

11H-Benzofuro[3,2-b][1]benzopyran-11-one, 2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)-

sanggennon D

Sanggenone C

sanggenone D