Methoxsalen-d3

Modify Date: 2024-01-31 02:34:38

Methoxsalen-d3 structure	Common Name	Methoxsalen-d3
	CAS Number	80386-99-8	Molecular Weight	219.20800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₅D₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Methoxsalen-d3

Methoxsalen-d3 is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].

Name	9-[(2H3)Methyloxy]-7H-furo[3,2-g]chromen-7-one

Description	Methoxsalen-d3 is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Alsharari SD, et al. Pharmacokinetic and Pharmacodynamics Studies of Nicotine After Oral Administration in Mice: Effects of Methoxsalen, a CYP2A5/6 Inhibitor. Nicotine Tob Res. 2014 Jan;16(1):18-25.

Molecular Formula	C₁₂H₅D₃O₄
Molecular Weight	219.20800
Exact Mass	219.06100
PSA	52.58000
LogP	2.54780

Methoxsalen-d3

Use of Methoxsalen-d3

Names

Methoxsalen-d3 Biological Activity

Chemical & Physical Properties