Glaucocalyxin A

Modify Date: 2024-01-03 08:45:33

Glaucocalyxin A structure	Common Name	Glaucocalyxin A
	CAS Number	79498-31-0	Molecular Weight	332.434
	Density	1.2±0.1 g/cm3	Boiling Point	513.4±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₈O₄	Melting Point	219.5-220.5℃
	MSDS	N/A	Flash Point	278.4±26.6 °C

Use of Glaucocalyxin A

Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect[1].

Name	ent-7β,14α-Dihydroxy-16-kauren-3,15-dione
Synonym	More Synonyms

Description	Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	PI3K Akt
In Vitro	Glaucocalyxin A induces apoptosis by mitochondrial apoptotic pathway through several steps including increasing the Bax/Bcl-2 ratio, triggering the intracellular reactive oxygen species (ROS) generation, reducing mitochondrial membrane potential (MMP), and inducing cleavage of caspase-9 and caspase-3[1].
References	[1]. Zhu J, et al. Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nucleartranslocation via regulating PI3K/Akt pathway. Cell Death Dis. 2018 Jun 13;9(6):708.

Density	1.2±0.1 g/cm3
Boiling Point	513.4±50.0 °C at 760 mmHg
Melting Point	219.5-220.5℃
Molecular Formula	C₂₀H₂₈O₄
Molecular Weight	332.434
Flash Point	278.4±26.6 °C
Exact Mass	332.198761
PSA	74.60000
LogP	0.88
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.574
Storage condition	2-8°C

ent-7,14-Dihydroxy-16-kauren-3,15-dione

Glaucocalyxin A

(5β,7α,8α,9β,10α,13α,14R)-7,14-Dihydroxykaur-16-ene-3,15-dione

BioBioPha
China
Product Name: Glaucocalyxin A
Price: ￥Inquiry/10mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Glaucocalyxin A
Price: ￥1228.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Glaucocalyxin A
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥1120/1 mg

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Glaucocalyxin A

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