Picoprazole

Modify Date: 2025-08-22 10:41:44

Picoprazole structure	Common Name	Picoprazole
	CAS Number	78090-11-6	Molecular Weight	343.40000
	Density	1.41g/cm3	Boiling Point	597.1ºC at 760 mmHg
	Molecular Formula	C₁₇H₁₇N₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	314.9ºC

Use of Picoprazole

Picoprazole is a specific inhibitor of H+/K+-ATPase with IC50 of 3.1±0.4 μM.

Name	methyl 6-methyl-2-[(3-methylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole-5-carboxylate
Synonym	More Synonyms

Description	Picoprazole is a specific inhibitor of H+/K+-ATPase with IC50 of 3.1±0.4 μM.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump Research Areas >> Metabolic Disease
Target	IC50: 3.1±0.4 μM (H+/K+-ATPase)[1]
In Vitro	Picoprazole inhibits the H+/K+-ATPase activity in a concentration-dependent manner. The IC50 value is 3.1±0.4 μM[1]. Picoprazole is a specific inhibitor of H+/K+-ATPase and binds to 100-kDa polypeptides of the enzyme, dose dependently inhibited opening of the Cl- conductance by Cu2+-o-phenanthroline, indicating that the Cl- conductance is part of the function of the H+/K+-ATPase[2]. The inhibitory effect of the three benzimidazole derivatives Timoprazole, Picoprazole, and Omeprazole on histamine and dbcAMP stimulated 14C-aminopyrine accumulation (H+ secretion) has been studied in isolated and enriched guinea-pig parietal cells. All compounds tested inhibit H+ secretion in a concentration dependent manner with IC50 values of 8.5±1.9 μM for Timoprazole, 3.9±0.7 μM for Picoprazole, and 0.13±0.03 μM for Omeprazole[3].
References	[1]. Beil W, et al. Inhibition of partially purified H⁺/K⁺-ATPase from guinea-pig isolated and enriched parietal cells by substituted benzimidazoles. Br J Pharmacol. 1984 Jul;82(3):651-7. [2]. Takeguchi N, et al. Disulfide cross-linking of H,K-ATPase opens Cl- conductance, triggering proton uptake in gastric vesicles. Studies with specific inhibitors. J Biol Chem. 1986 Feb 25;261(6):2560-6. [3]. Sewing KF, et al. Effect of substituted benzimidazoles on acid secretion in isolated and enriched guinea pig parietal cells. Gut. 1983 Jun;24(6):557-60.

Density	1.41g/cm3
Boiling Point	597.1ºC at 760 mmHg
Molecular Formula	C₁₇H₁₇N₃O₃S
Molecular Weight	343.40000
Flash Point	314.9ºC
Exact Mass	343.09900
PSA	104.15000
LogP	3.53480
Index of Refraction	1.684
Storage condition	2-8℃

Picoprazolum

methyl 6-methyl-2-[[(3-methyl-2-pyridyl)methyl]sulfinyl]-5-benzimidazolecarboxylate

Picoprazol

Picoprazole

Picoprazole (INN)

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Picoprazole?
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1H-Benzimidazole-6-carboxylicacid, 5-methyl-2-[[(3-methyl-2-pyridinyl)methyl]sulfinyl]-, methyl ester
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

Picoprazole suppliers

Price: $696/1mg

Reference only. check more Picoprazole price

Picoprazole

Use of Picoprazole

Names

Picoprazole Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.