acedapsone

Modify Date: 2025-08-22 13:54:35

acedapsone Structure
acedapsone structure
Common Name acedapsone
CAS Number 77-46-3 Molecular Weight 332.37400
Density 1.362g/cm3 Boiling Point 661ºC at 760 mmHg
Molecular Formula C16H16N2O4S Melting Point 289-292°
MSDS N/A Flash Point 353.6ºC

 Names

Name N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.362g/cm3
Boiling Point 661ºC at 760 mmHg
Melting Point 289-292°
Molecular Formula C16H16N2O4S
Molecular Weight 332.37400
Flash Point 353.6ºC
Exact Mass 332.08300
PSA 100.72000
LogP 3.66300
Index of Refraction 1.625

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AE7175000
CHEMICAL NAME :
Acetanilide, 4',4'''-sulfonylbis-
CAS REGISTRY NUMBER :
77-46-3
BEILSTEIN REFERENCE NO. :
2164071
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C16-H16-N2-O4-S
MOLECULAR WEIGHT :
332.40
WISWESSER LINE NOTATION :
1VMR DSWR DMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 61,617,1939 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4200 mg/kg/43W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors Blood - lymphoma, including Hodgkin's disease
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 24,149,1960

 Synthetic Route

 Synonyms

Acetamin
Acedapsone
Hansolar
4,4'-diacetamidodiphenyl sulphone
4,4'-bis(acetylamino)diphenyl sulfone
N,N'-[4,4'-sulfinylbis(4,1-phenylene)]diacetamide
DADDS
Diacetyldapsone
Sulfadiamine
4,4'''-sulfonylbis(acetanilide)
4,4'-diacetylaminodiphenylsulphone
Camilan
4,4'-di-N-acetylaminodiphenyl sulfone
Sulfodiamine
Rodilone
Sulfodiamin
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