Glycerol-d3

Modify Date: 2024-01-02 12:05:10

Glycerol-d3 structure	Common Name	Glycerol-d3
	CAS Number	7325-16-8	Molecular Weight	95.11230
	Density	1.302 g/mL at 25ºC	Boiling Point	182ºC(lit.)
	Molecular Formula	C₃H₅D₃O₃	Melting Point	20ºC(lit.)
	MSDS	Chinese USA	Flash Point	>230 °F

Use of Glycerol-d3

Glycerol-d3 is the deuterium labeled Glycerol[1]. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[2][3][4].

Name	1,2,3-trideuteriooxypropane
Synonym	More Synonyms

Description	Glycerol-d3 is the deuterium labeled Glycerol[1]. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[2][3][4].
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Pennings S, et al. Effect of glycerol on the separation of nucleosomes and bent DNA in low ionic strengthpolyacrylamide gel electrophoresis. Nucleic Acids Res. 1992 Dec 25;20(24):6667-72. [3]. Yazdani SS, et al. Anaerobic fermentation of glycerol: a path to economic viability for the biofuelsindustry. Curr Opin Biotechnol. 2007 Jun18(3):213-9. [4]. Huang ZH, et al. Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure. Eur J Pharmacol. 2000 Oct 20406(3):453-60.

Description

Glycerol-d3 is the deuterium labeled Glycerol[1]. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Pennings S, et al. Effect of glycerol on the separation of nucleosomes and bent DNA in low ionic strengthpolyacrylamide gel electrophoresis. Nucleic Acids Res. 1992 Dec 25;20(24):6667-72.

[3]. Yazdani SS, et al. Anaerobic fermentation of glycerol: a path to economic viability for the biofuelsindustry. Curr Opin Biotechnol. 2007 Jun18(3):213-9.

[4]. Huang ZH, et al. Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure. Eur J Pharmacol. 2000 Oct 20406(3):453-60.

Density	1.302 g/mL at 25ºC
Boiling Point	182ºC(lit.)
Melting Point	20ºC(lit.)
Molecular Formula	C₃H₅D₃O₃
Molecular Weight	95.11230
Flash Point	>230 °F
Exact Mass	95.06620
PSA	60.69000
Index of Refraction	n20/D 1.4676(lit.)

Glycerol-d3 MSDS(Chinese)

RIDADR	NONH for all modes of transport

Methanol-d4

CAS#:811-98-3

Triacetin

CAS#:102-76-1

Methan-d3-ol,ac...

CAS#:24704-57-2

Glycerol-d3

CAS#:7325-16-8

Literature: Neverov, Alexei A.; McDonald, Todd; Gibson, Graham; Brown Canadian Journal of Chemistry, 2001 , vol. 79, # 11 p. 1704 - 1710

Precursor 2
CAS#:811-98-3 Methanol-d4 CAS#:102-76-1 Triacetin
DownStream 0

Tri-O-deuterio-glycerin

MFCD00064295

Tris-O-deutero-propan-1,2,3-triol

O-Trideuterio-glycerin

glycerol-OD3

O,O',O''-trideuterio-propane-1,2,3-triol

glycer(ol-d3)

Glycerol-d3

Use of Glycerol-d3

Names

Glycerol-d3 Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Synthetic Route

Precursor & DownStream

Synonyms